Cellular Biologist

Topos Bio • South San Francisco, CA

13d

About The Position

At Topos Bio, we're pioneering drug discovery for intrinsically disordered proteins—targets that have eluded conventional approaches in neurodegeneration, oncology, and cardiometabolic disease.
We're seeking a cell biologist to develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts. You'll work at the interface of disease biology, protein biophysics, and drug screening.

Requirements

• Strong foundation in mammalian cell culture and cellular assay development
• Experience with disease-relevant cellular models
• Ability to troubleshoot complex biological systems and optimize experimental protocols
• Track record of productivity and effective collaboration

Nice To Haves

• PhD in cell and molecular biology with focus on disease models
• Industry experience in drug discovery or biotech
• Experience with reporter assays and high-throughput screening platforms
• Familiarity with oncology, neurodegeneration, or metabolic disease models
• Track record of developing novel cellular assays or screening approaches

Responsibilities

• Develop and optimize mammalian cell-based assays for disordered protein targets
• Execute phenotypic and reporter-based screening campaigns to validate computational hits
• Characterize compound activity and support structure-activity relationship studies
• Collaborate with computational scientists to integrate experimental data with modeling workflows
• Establish robust assay protocols and quality control metrics

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree