The Zimmerman lab at OUHSC is broadly focused on understanding the function of monocytes and tissue resident macrophages in mouse models of polycystic kidney disease (PKD), acute kidney injury (AKI), and heart failure with preserved ejection fraction (HFpEF) using state-of-the-art techniques including single cell RNA sequencing (scRNAseq) and spatial transcriptomics. Using omics’ approaches, we have defined how disease sequalae alters macrophage phenotype in mouse models and developed monocyte/macrophage specific knockout mice to test the functional importance of predicted cytokines in vivo. We have also set our sights on understanding how omics data from human patients cross-references across model systems including mice, rat, and organoids using deep learning approaches. Responsible for providing bioinformatics support for research projects, constructing and maintaining databases, and writing programs. Assists researchers by collecting data, keeping records, conducting literature and technical research, analyzing data, preparing reports, and working with other bioinformatics support personnel. Assists with experimental design and interpretation of results.