Bioinformaticist - Psychiatry

Washington University in St. Louis • Watervliet, MI

67d • $55,200 - $100,000

About The Position

The NeuroGenomics and Informatics (NGI) group at WashU Medicine is recruiting a Human Statistical Genomicist to work in Dr. Cruchaga’s lab at the WashU Medicine. The NGI holds whole exome and genome sequencing data from over 10,000 subjects that is locally generated or from public repositories. At the NGI we are constantly growing our dataset and generating new data-freezes; as such we are constantly improving and updating our pipelines to keep up with advances in the field. We are seeking a talented and motivated employee to make important contributions to the study of the genetics of Alzheimer Disease and related dementias. This position will work directly with the head of the Genomics Unit at the NGI to organize, develop, implement, and manage genome sequencing data pipelines that will be used in downstream analysis and projects. They will join a team of computational and statistical researchers working in bioinformatics, statistical genomics, and genetics. The team comprises over 20 people dedicated to understanding the architecture of neurodegenerative diseases.

Requirements

• Bachelor's degree.
• 4 years of research experience.
• Experience handling hundreds-to-thousands of samples at once from different batches and how to deal with potential derived artifacts.
• Expertise with BWA-MEM, GTAK.
• Experience with analysis tools such as PLINK, SKAT, SKAT-O, METAL, rare-METAL and other gene burden tools.
• Advanced knowledge of Unix-based operating systems.
• Proficient in computing skills and knowledge of R, Python, and/or similar scripting languages.
• Experience using common software (Excel, R, ggplot, PowerPoint, etc.) for preparing and presenting reports, figures, and graphic data representations.

Nice To Haves

• Master's degree in Human and Statistical Genetics.
• 4 years of experience in bioinformatics or related discipline.
• Skills in ability to reason, analytical thinking, big data processing, bioinformatics tools, biostatistics, communication, complex data analysis, computational biology, data management, data presentations, discrete mathematics, genome sequencing, ggplot, human genomics, machine learning, Microsoft Office, Perl programming, PLINK (Software), probabilistic modeling, Python (Programming Language), statistics, system administration.

Responsibilities

• Revise and improve existing WES and WGS data processing and analysis pipelines, including QC, data organization, and back up.
• Consistently improve pipelines as datasets/requirements change and adapt to new computational environments.
• Provide advice on data processing and analysis to other team members.
• Assist other team members in receiving and sharing data from collaborators.
• Manage, teach, and supervise junior scientists in processing sequencing data.
• Participate in meetings within the group and with other institutions and investigators.
• Assist in manuscript, grant, and report writing sections such as materials and methods and results.

Benefits

• Up to 22 days of vacation, 10 recognized holidays, and sick time.
• Competitive health insurance packages with priority appointments and lower copays/coinsurance.
• Free Metro transit U-Pass for eligible employees.
• Defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%.
• Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more!
• 4 weeks of caregiver leave to bond with your new child.
• Tuition coverage for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Bachelor's degree