Bioengineering Scientist

CAMRIS International•Bethesda, MD

12d•Onsite

About The Position

Overview We are seeking a Bioengineering Scientist to support the National Institutes of Health’s (NIH), world renowned National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda, MD. Our NIAID professional, technical, and scientific support personnel are part of a preeminent team focused on positively impacting millions of lives around the world with groundbreaking research. Candidates will work at a prominent and vibrant NIAID worksite to directly support exciting ongoing research activities as a contractor team member. Accelerate your career and apply below to help us make a difference. CAMRIS International is a dynamic clinical research and international development firm that achieves innovative solutions to health and development challenges through high-quality, cost-effective programs and research management services. We combine our proven systems with today’s most effective, evidence-based best practices. Our core practice areas include: clinical research; vaccine research, microbiology and infectious disease research, development and production; biodefense; global health security; and HIV/AIDS programs. Our employees enjoy a collegial environment where individual contributions matter at all levels. At CAMRIS, you will notably improve the lives of people at home and abroad.

Requirements

Ph.D. in bioengineering, mechanical engineering, or physics and 2+ years of experience.
Professional competency with design and fabrication of microfluidic devices, including flow based droplet generators, using soft lithography (i.e., template design/production and device generation in polydimethylsiloxane [PDMS]) and glass fabrication techniques.
Professional competency with operation of the Pacific Biosciences Revio single-molecule real time (SMRT) sequencer platform.
Professional competency with basic bioinformatic and evolutionary biology tools for sequence analysis, including current softwares for database searches, multiple sequence alignment generation, and phylogenetic inference.
Professional competency with RNA extraction from human blood and body fluid samples, reverse transcription, polymerase chain reaction, and sequencing library preparation and quality control.
Intensive experience with laboratory automation, including liquid handling systems.
Experience with the application of complex bioinformatic pipelines for next-generation sequence data analysis.
Working understanding of human immunology, with emphasis on innate and adaptive antiviral host responses.
Track record of high-profile, peer-reviewed, first-author publication in the field of bioengineering.
Track record of high-profile, peer-reviewed, first-author publication in the field of virus evolution.
Track record of high-impact publications related to RNA virus infections.

Responsibilities

Develop microfluidics-based approaches for analysis of intra-host virus diversity and evolution, such as:
An approach for high-throughput, single-copy, full-length sequencing of purified virus genomes, to include the following:
Optimized virus inactivation and nucleic acid extraction procedures from blood and body fluids.
Customized microfluidic devices, regimes of operation, and reagents that partition extracted virus genomes in aqueous solution into monodisperse water-in-oil emulsions and thus enable downstream single-copy analysis.
An approach for high-throughput sequencing of individual intact virions, to include the following:
Non-destructive procedures for abrogating the infectivity of intact virions in suspension.
Customized microfluidic devices, regimes of operation, and reagents that can partition single-virion suspensions into water-in-oil emulsions at limiting dilution and thus enable downstream single-virion analysis.
Maintain records of all work using appropriate electronic systems.
Present results at internal and external meetings.
Collaborate with NIH and non-NIH scientists.
Train other NIH scientists in methods under development.
Contribute to original research manuscripts describing findings.
Additional duties as assigned.

Benefits

CAMRIS offers a comprehensive benefits package, including medical, dental, and vision insurance for individuals and families, FSAs, HSA, life and AD&D insurance, short- and long-term disability, legal services, voluntary hospital indemnity, critical illness and accident insurances, EAP, pet insurance, 401(k) with employer match and Roth option, tuition and professional reimbursement, public transportation support in the DMV area, a referral bonus program, vacation with tenure-based increases, PTO, 11 paid holidays, paid bonding leave, and paid supplemental short-term disability.

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