Bioconjugation Lead

Astellas Pharma, Inc.•South San Francisco, CA

63d

About The Position

Bioconjugation Lead Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas! Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com. The Role This pivotal role involves providing strategic, scientific, and operational leadership for our antibody drug conjugate (ADC) research, primarily focusing on bioconjugation strategies and their interplay with antibody characteristics. The position holder will drive the design and development of novel ADC candidates and support the Research Lead (Res-L) from a scientific and resource management perspective to accelerate projects. This position reports directly to the Head of Antibody Drug Conjugate

Responsibilities

Provide scientific vision, strategic direction, and technical oversight for the Bioconjugation team, ensuring the delivery of well-characterized ADC candidates.
Collaborate closely with the Antibody Engineering team to define optimal antibody characteristics for conjugation and contribute to the antibody selection strategy for ADC projects
Lead the design, development, optimization, and execution of novel and established bioconjugation methodologies for creating ADCs, including site-specific conjugation techniques.
Stay at the forefront of bioconjugation technologies, ADC development, and relevant analytical advancements; evaluate and implement new technologies and approaches to enhance team capabilities and productivity.
Troubleshoot and resolve complex scientific and technical challenges related to bioconjugation, purification, and characterization
Lead, manage, mentor, and develop a team, fostering a culture of scientific excellence, innovation, collaboration, urgency, and accountability.
Ensure appropriate resource allocation, project planning, and timeline management for the Bioconjugation team.
Drive bioconjugation aspects of ADC projects from early discovery to development candidate selection, ensuring timely delivery of high-quality data and materials.
Collaborate effectively with cross-functional teams, including antibody engineering, medicinal chemistry (payload and linker synthesis), analytical development, DMPK, pharmacology, CMC, and external partners.
Contribute to the preparation of technical reports, patent applications, and regulatory submission documents.