Genentech-posted 9 months ago
$120,700 - $262,900/Yr
Full-time • Senior
South San Francisco, CA
Chemical Manufacturing

We advance science so that we all have more time with the people we love. A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 45 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work. We are looking for a versatile Scientist to work within the Complex in vitro Systems (CiS) Laboratory, where we design, develop, and characterize complex in vitro models (CIVM) to support the larger Development Sciences, Research, and Translational Medicine departments of Genentech. In particular, the individual will be responsible for providing scientific and technical expertise to automate scaling, processing, and assays using CIVMs. Currently the CIVMs include 3D multicellular models consisting of organoids and spheroids with aspiration to automate microfluidic organ-on-chip technologies. This laboratory-based role will focus on employing newly installed automation tools to support both discovery and preclinical development portfolios broadly through multiple contexts of use, including safety, disposition, biomarker development, and pharmacodynamic responses.

  • Establishing, qualifying, and implementing innovative, state-of-the-art technologies/platforms, including automated organoid culture and liquid handling systems.
  • Performing hands-on lab work, including sitting or standing for extended periods, performing repetitive tasks such as cell culture, pipetting, and labeling tubes.
  • Executing techniques that require a high degree of manual dexterity and physical activity.
  • Handling potentially hazardous materials, including chemotherapeutics, biological hazards, and human primary cells.
  • Collaborating with colleagues and departments across multiple functions in Genentech Research & Early Development (gRED).
  • Translating lab experiments developed by individual scientists into automation-ready protocols that can run repeatedly at scale.
  • Overseeing and managing the seamless operation of multiple sophisticated, scheduled workflows for automated culture systems.
  • PhD in biomedical engineering, chemical engineering, mechanical engineering, biomaterials, immunology, pharmacology, cellular or molecular biology, toxicology, pharmaceutical sciences, or a related field.
  • Experience in either academia, pharmaceutical, biotechnology, or CRO industry related to the automation and/or implementation of CIVMs.
  • Hands-on experience with at least several cellular assays (cell viability, flow cytometry, gene expression analysis, high content screening, 3D imaging analysis, biomarker quantification, transepithelial electrical resistance (TEER), etc.).
  • Track record of translating hands-on cell culture work into automated protocols.
  • Experience operating, programming, and integrating automation instrumentation and peripherals.
  • Experience with automation scheduling software (e.g. GreenButtonGo, Thermo Momentum, HiRes Cellario, etc.) is highly preferred.
  • Strong organizational skills, attention to detail, ability to prioritize tasks, interact professionally and present data to all levels of staff and external partners.
  • Hands-on experience with primary cell cultures in 3D (could be organoids, layered cultures, or spheroid work).
  • Experience with integrating instrument and process quality control (QC) data with LIMS tools.
  • Knowledge of databases, cloud computing, and programming languages such as Python/C++/R as well as workflow scripting for liquid handling systems.
  • Experience managing/scheduling/tracking multiple projects simultaneously establishing expectations and maintaining clear communication with stakeholders.
  • Experience implementing project management software.
  • Relocation benefits are available for this job posting.
  • A discretionary annual bonus may be available based on individual and Company performance.
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