Arc Institute-posted 3 months ago
$158,500 - $196,500/Yr
Full-time • Mid Level
Palo Alto, CA
101-250 employees

We are seeking a highly skilled Automation Engineer to join our Multiomic Technology Center and lead the design, development, implementation, and optimization of complex lab automation workflows. The role will work closely with cross-functional teams, analyze the needs and requirements of high throughput 2D and 3D stem cell culture, genome engineering, and downstream single cell and NGS analysis workflows, design and develop streamlined solutions to transfer manual processes to automated platforms. The role requires a strong understanding of approaching biological systems with an engineering mindset to design automation that accounts for the complexity of model systems. This role is crucial for enabling high-quality, large-scale data generation for our ambitious Virtual Cell and Alzheimer's Disease Initiatives. These initiatives aim to create the first foundational model capable of accurately predicting cellular states and their responses to intervention, ultimately leading to a better understanding and treatment of complex neurodegenerative diseases.

  • Collaborate with wet lab scientists to analyze current manual workflows, identify bottlenecks, draft system requirements, and develop plans to transfer manual processes to automated systems
  • Develop, implement, and optimize robotic and software-based automation solutions, primarily focusing on automating stem cell culture, molecular and cell-based assays
  • Program and troubleshoot current liquid handling and robotic systems; select, onboard, and integrate new instrumentations
  • Program control software and integrate various instruments into cohesive workflows
  • Design and implement data integration methodology to ensure seamless data transfer between hardwares and to LIMS
  • Design, coordinate, and execute validation experiments to ensure precision, accuracy, and reproducibility of results
  • Troubleshoot and resolve technical issues related to automation systems, and develop systematic methodology for troubleshooting complex issues
  • Train scientists and lab staff on newly implemented automated equipment and protocols
  • Coordinate equipment on-boarding, maintenance, and calibration for automated systems
  • Present plans, results and technical recommendations to stakeholders internally and externally
  • Bachelor's degree or above in Engineering, Biotechnology, Molecular Biology, Cell Biology, or a related field
  • 6+ years for BS (or 4+ years for MS) of hands-on experience designing, implementing, and maintaining laboratory automation systems
  • Experience programming and optimizing liquid handling methods
  • Experience interfacing, integrating and scheduling multiple laboratory instrumentations
  • Proficiency in programming languages such as Python or C#
  • Experience integrating and managing data with LIMS
  • Demonstrated experience with cell culture automation
  • Familiarity with mammalian cell culture, genomics, molecular and cell-based assays
  • Demonstrated ability to apply engineering solutions in the context of biological workflows (e.g. cell culture, genome engineering, single-cell assays) with an understanding of the underlying biology
  • Familiarity with DoE (Design of Experiments) principles and best practices and statistical analysis
  • Excellent problem-solving and troubleshooting skills
  • Attention to detail and strong organization skills
  • Strong communication skills to collaborate effectively with cross-functional teams
  • Ability to work independently and manage multiple projects simultaneously
  • Experience in high-throughput production environments or high throughput screening applications
  • Experience with human stem cell culture, organoids, molecular engineering, or single cell analysis methods
  • Base salary range of $158,500 to $196,500
  • Annual discretionary bonus based on individual and institute performance factors
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