Associate Scientist/Scientist I, Biochemistry Screening & Biophysical Characterization

Flagship Pioneering, Inc.•Boston, MA

46d•Onsite

About The Position

Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. We are pioneering the development of Synteins, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional scientists who are passionate about driving therapeutic modality innovation in biotechnology. Abiologics was founded in Flagship Pioneering's venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines were conceived and created. Since Flagship's founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents. We are seeking a biochemist to design, develop, and execute biochemical and biophysical strategies that enable the discovery and optimization of Synteins. The ideal candidate brings hands-on expertise in assay development, primary and secondary biochemical screening, and orthogonal biophysical characterization to establish target engagement, binding kinetics/thermodynamics, and mechanism of action. This role is highly collaborative, partnering closely with medicinal chemistry, computational sciences, and pharmacology.

Requirements

PhD in Biochemistry, Biophysics, Chemical Biology, or related field with 0-1+ year of relevant experience; or MS with 6+ years; or BS with 8+ years in industry or equivalent.
Demonstrated, hands-on experience developing and running biochemical and/or biophysical assays to quantify ligand binding and target engagement.
Proficiency with core biophysical platforms (preferably BLI/SPR) and biochemical readouts (e.g., FP, TR-FRET/HTRF, AlphaLISA, enzymatic kinetics).
Track record of troubleshooting complex assay and protein reagent issues and delivering decision-enabling data on tight timelines.
Excellent communication and collaboration skills; ability to work effectively in cross-functional, fast-paced environments.

Responsibilities

Design, develop, and validate robust biochemical and biophysical assays for hit identification, hit triage, and lead optimization across diverse target classes (enzymes, PPIs, receptors, and challenging targets).
Execute and analyze small- to medium-scale screens including development of counterscreens and artifact mitigation strategies.
Perform quantitative biophysical characterization of ligand-target interactions, including affinity, kinetics, stoichiometry, and thermodynamics.
Apply a range of techniques such as SPR/BLI, fluorescence-based assays, and mass-spectrometry based assays; leverage orthogonal methods to confirm binding and establish MOA.
Ensure data quality and rigor through appropriate controls, reference standards, Z' factor assessments, and comprehensive data QC and troubleshooting.
Miniaturize and automate assays as appropriate; partner with automation/HTS teams and operate plate readers and liquid handling platforms.
Analyze, visualize, and interpret complex datasets; summarize findings and recommend next steps to project teams.
Proactively evaluate new technologies and methods to improve throughput, sensitivity, or mechanistic insight.
Maintain accurate electronic lab notebooks, author SOPs, and present results to cross-functional stakeholders.

Benefits

Abiologics, Inc currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.
Compensation and benefits information is based on Abiologics, Inc's good faith estimate as of the date of publication and may be modified in the future.

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