Associate Scientist / Principal Associate Scientist, Protein Analytics

Alloy Therapeutics • Waltham, MA

3d • $94,000 - $110,000 • Onsite

About The Position

We are Alloy Therapeutics—a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.

Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility. We are all one team!

Alloy's Protein Analytics group, within the Alloy Antibody Powered Division, provides analytical support across an array of discovery and development activities, including assay development, detailed biophysical characterization, high-throughput screening, and quality control of monoclonal and multispecific antibodies, TCRs, TCR mimics, and other modalities.

We are seeking a highly motivated Associate Scientist or Principal Associate Scientist to conduct in vitro screening and analytical characterization as part of our dynamic, fast-paced biotech team. In this role, you will design & execute Liquid Chromatography Mass-Spectrometry (LC-MS) experiments, purity assessments, recombinant protein-binding screens, and developability evaluations. You will work collaboratively in a matrixed environment to advance biologics discovery and support rapid, data-driven decision-making.

This role will report to the Head of Protein Analytics and offers significant autonomy, with ownership of multiple stakeholders, projects, and tasks in a dynamic start-up environment, while maintaining the pace and standards of Alloy.

Requirements

• B.S. and M.S. in Biochemistry or a related field, with 2-6 of relevant industry experience.
• Proven track record of expertise in various protein analytical and/or biophysical assessments.
• Hands-on experience with LC-MS, SEC-HPLC, CE-SDS, and/or related methodologies.
• Experience in the maintenance and troubleshooting of analytical instrumentation.
• Excellent written and verbal communication skills, with the ability to clearly present complex scientific data.
• Ability to effectively multitask and deliver results within project-driven timelines.
• Strong sense of ownership, urgency, persistence, and scientific integrity.
• Excellent organization, clear communication, and teamwork abilities in a multidisciplinary setting.
• Thrives working on a team and collaborating with others to achieve project goals.
• Enjoys a dynamic and exciting team environment.
• Detail oriented, with rigorous scientific thinking and a passion for drug discovery to improve patients' lives.

Nice To Haves

• Preferred experience with protein-binding (BLI, SPRi), and/or cell-binding (Flow Cytometry).
• Preferred experience with protein labelling, including biotinylation and fluorophore conjugation.
• Demonstrated ability to troubleshoot, maintain, and optimize analytical instrumentation.

Responsibilities

• Design and conduct LC-MS based experiments.
• Develop new methods and optimize existing workflows.
• Perform purity assessments (SEC-HPLC, CE-SDS, etc.).
• Maintain analytical instrumentation and ensure best practices are followed.
• Support protein binding assays using BLI (Octet) and SPRi (Carterra LSA).
• Support developability assessments utilizing an array of in vitro methods.
• Present experimental data and findings during team meetings.
• Ensure timely and successful execution of project activities according to plan.
• Maintain detailed and accurate laboratory records in compliance with industry standards.
• Maintain laboratory organization and ensure compliance with safety protocols.

Benefits

• Competitive base and equity compensation commensurate with level of experience and independence
• 401(k) company match
• Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
• Company-paid disability (STD, LTD) and life insurance
• Paid parental leave
• Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
• Unlimited PTO (paid time off) and flexible schedules
• Annual stipend for continuing education with commitment to your career through individualized professional development plan
• Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level