Associate Scientist, Late-Stage Purification Process Development
About The Position
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. We are seeking to hire an Associate Scientist to join our Purification Process Development team. The successful candidate will be responsible for supporting late-stage downstream process development activities for our large molecule pipeline.
Requirements
- BS/MS in Biology, Biochemistry, Chemical Engineering or related scientific discipline with 3+ years of industry experience
- Experience in protein characterization, design of experiments and analytics
- Experience monitoring downstream GMP and/or pilot production unit operations
- Hands-on experience with AKTA protein purification systems, lab-scale TFF systems and antibody characterization methods including: HPLC, LC/MS, SDS‐PAGE, DLS and other biophysical techniques
- Excellent critical thinking, scientific problem-solving and communication skills
Nice To Haves
- Prior experience in a late-stage process development setting is preferred
Responsibilities
- Support purification process characterization, validation, PPQ and BLA-enabling activities.
- Monitor process performance, trend data, and coordinate sample handling from GMP manufacturing campaigns.
- Extract and organize data for report and submission authoring and contribute to statistical analysis.
- Support tech transfer for and GMP campaign readiness.
- Execute lab-scale chromatography and filtration studies to inform late-stage data packages.
- Execute in-process testing using ELISA, HPLC, UV and SDS-Page based analytics
- Summarize key experimental data and document all experiments in an electronic lab notebook in a timely manner.
- Collaborate closely with colleagues in CMC, Discovery and other functions to achieve project goals.
Benefits
- Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Number of Employees
251-500 employees
