Associate Scientist, in vivo Pharmacology

Stoke Therapeutics, Inc.•Bedford, MA

65d•$114,000 - $138,000

About The Position

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights STK-002 is Stoke's proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals. Stoke's initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach. Position Purpose: Stoke is seeking an enthusiastic and highly motivated Associate Scientist to join the In Vivo Pharmacology Department. This position is an opportunity to learn new techniques and concepts, be creative, and grow with a growing company.

Requirements

BS with 7+ years post-graduate experience or M.S. with 4+ years of experience working in a biotechnology or pharmaceutical company or contract research organization.
Experience working with animal disease models.
Experience with animal behavioral assays.
Experience with subcutaneous and intravenous injections in rodents; intracerebroventricular injection experience a plus.
Experience with molecular biology assays such as PCR, ELISA, MSD, BCA, Western Blot (or JESS).
Strong organizational skills and attention to detail.
Strong verbal and written communication skills.
Creative thinking and working well in a team environment.

Nice To Haves

Experience in neuroscience a plus.
Experience with ISH/IHC a plus.

Responsibilities

Design and execute routine studies to investigate the PK/PD and efficacy of drug candidates.
Perform routine to intermediate handling procedures and injections, monitor animal health, and collect tissues in mice.
Perform moderately complex behavioral experiments in animal models.
Support the implementation of new animal models.
Demonstrate technical proficiency to investigate, identify, develop, optimize, and troubleshoot new methods/ techniques/ instrumentation to address critical project needs.
Read and understand scientific literature.
Analyze data, author technical reports, and document experiments in an electronic notebook.
Participate and present at project team and departmental meetings.
Maintain laboratory organization including equipment upkeep and ensure compliance with safety protocols.
Collaborate across functional areas.