Associate Scientist II, Pilot Plant Operations

AstraZeneca • New Haven, CT

1d

About The Position

This is what you will do: The Associate Scientist is responsible for performing assigned tasks to support the operational scale up of non-GMP Pilot-scale manufacturing processes for Alexion’s biotherapeutic candidates. The Associate Scientist will work routinely in collaboration with other members of Pilot Plant Operations and other groups in Product Development and Clinical Supply organization. You will be responsible for: Support of pilot scale operations at up to 500L bioreactor scale of cell culture and corresponding downstream purification process: Assisting in general facility and operational support, including maintenance of lab and pilot scale equipment, equipment and parts cleaning, solution making, set up and clean-up activities, and hands on support of upstream and downstream operations as needed during manufacturing runs. Documenting results in electronic notebooks and/or paper forms Availability during standard working hours is expected as well as occasional after hours, shift work or weekend work as may be necessary. You will need to have: BS degree in Biochemistry, Chemistry, Chemical Engineering, or related scientific discipline from an accredited university, with 1 - 2 years’ experience or MS with 0–1-year experience. Proficiency in following various laboratory and manufacturing operating and safety procedures is required. Experience with biologics manufacturing or research with mammalian cell culture and/or protein purification. Proficiency with basic laboratory skills (i.e.: pipetting/volumetric measurements, weighing components, pH/conductivity measurements) Ability to work independently and as part of a team. Excellent organizational skills Ability to perform tasks accurately and reproducibly. Understands/acts on priority of assigned tasks under direct supervision to deliver tasks within established timelines. Proficiency with MS Office programs, including Word, Excel, and Outlook. We would prefer you to have: Critical thinking skills: Following basic Scientific / Engineering Principles routinely identifies a problem and escalate accordingly, can work cross-functionally to solve routine technical problems. Scientific Inquisitiveness: Understands background of assigned technical tasks and be a resource for others. Demonstrates ability to delve deeper into technical topics, seeks to incorporate ideas from conferences or literature into work processes. Communication skills: routinely delivers effective technical presentations within functional group, Drafts, edits and finalizes technical documents without templates and with minimal supervision, Works collaboratively with own group to achieve shared objectives. Technical expertise: Conducts assigned routine tasks in the scale up area with limited supervision, operational experience with Pilot Scale bioreactors, and/or chromatography skids is a plus. Strategic ability: Regularly interacts with peers within same functional group. Ownership: Works with supervisor and coworkers to ensure assigned tasks are completed, Understands/acts on priority of assigned tasks under direct supervision Demonstrates ability to manage aspects of a technical project. Date Posted 25-Feb-2026 Closing Date 03-Mar-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. For over three decades, patients and their caregivers have been at the center of everything we do. Every day, we are inspired to follow the science and think differently to create better outcomes for them and their families. Our mission is driven by understanding who they are as unique individuals, not solely defined by their diseases. We’re a leading rare disease company with a diversified projects. Our pioneering legacy in rare diseases is rooted in being the first to translate the complex biology of the complement system into transformative medicines over the past three decades. Today, we continue to push the boundaries of science and deepen our understanding of rare diseases with patient-centricity at the core. This knowledge allows us to innovate and evolve into new areas where needs are unmet and provide an opportunity to help people fully live their best lives.

Requirements

• BS degree in Biochemistry, Chemistry, Chemical Engineering, or related scientific discipline from an accredited university, with 1 - 2 years’ experience or MS with 0–1-year experience.
• Proficiency in following various laboratory and manufacturing operating and safety procedures is required.
• Experience with biologics manufacturing or research with mammalian cell culture and/or protein purification.
• Proficiency with basic laboratory skills (i.e.: pipetting/volumetric measurements, weighing components, pH/conductivity measurements)
• Ability to work independently and as part of a team.
• Excellent organizational skills
• Ability to perform tasks accurately and reproducibly.
• Understands/acts on priority of assigned tasks under direct supervision to deliver tasks within established timelines.
• Proficiency with MS Office programs, including Word, Excel, and Outlook.

Nice To Haves

• Critical thinking skills: Following basic Scientific / Engineering Principles routinely identifies a problem and escalate accordingly, can work cross-functionally to solve routine technical problems.
• Scientific Inquisitiveness: Understands background of assigned technical tasks and be a resource for others. Demonstrates ability to delve deeper into technical topics, seeks to incorporate ideas from conferences or literature into work processes.
• Communication skills: routinely delivers effective technical presentations within functional group, Drafts, edits and finalizes technical documents without templates and with minimal supervision, Works collaboratively with own group to achieve shared objectives.
• Technical expertise: Conducts assigned routine tasks in the scale up area with limited supervision, operational experience with Pilot Scale bioreactors, and/or chromatography skids is a plus.
• Strategic ability: Regularly interacts with peers within same functional group.
• Ownership: Works with supervisor and coworkers to ensure assigned tasks are completed, Understands/acts on priority of assigned tasks under direct supervision Demonstrates ability to manage aspects of a technical project.

Responsibilities

• Support of pilot scale operations at up to 500L bioreactor scale of cell culture and corresponding downstream purification process
• Assisting in general facility and operational support, including maintenance of lab and pilot scale equipment, equipment and parts cleaning, solution making, set up and clean-up activities, and hands on support of upstream and downstream operations as needed during manufacturing runs.
• Documenting results in electronic notebooks and/or paper forms
• Availability during standard working hours is expected as well as occasional after hours, shift work or weekend work as may be necessary.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level