Associate Scientist II, Nonclinical & Immunoassay

Vaxcyte•San Carlos, CA

5d•$105,000 - $122,000

About The Position

Vaxcyte is looking for an energetic and talented Associate Scientist II to manufacture and test all reagents required for immunoassay detection of multi-valent vaccines. In particular, the reagents we are using need to be conjugated to different entities and then characterized and catalogued for our multiplexed assays. Extreme control of this assay is required to maintain DS shelf life and more importantly, ensuring DP compounding is successful in relation to the final dose of each DS in the clinic. We require an Associate Scientist II who will continue the development and optimization of assay suites for our current 3 programs, and for upcoming research projects. This person will be part of a larger team that will continue this development. The role requires an extremely high level of organization, and the ability to maintain large volumes of data for the various DS and DP entities.

Requirements

Bachelor’s degree (BSc) in Molecular Biology, Chemistry, Analytical Chemistry, or Organic Biochemistry with a minimum 2 years of relevant experience, or Master’s degree (MSc) in the same fields with minimum 1 year of relevant experience or an equivalent combination of education and experience.

Nice To Haves

Ideal candidate will have a significant background in plate-based assay development and antibody characterization including Akta, HPLC and BLI.
Experience in protein analysis such as SEC, HPLC, SDS-page, CE-SDS, and cIEF and binding kinetics is a plus.
Having a high degree of organizational capabilities for both reagents and experimental scheduling a must.
Prior experience of transferring methods to external partners for validation and GMP will be of a significant benefit, and first-hand experience of a QC environment would also be advantageous.
Experience in immunoassay development, qualification, validation, trouble shooting and aiding in OOS investigations is highly desired.
The ability to present complex data sets and independently propose and design follow-up experiments are also required.

Responsibilities

Help continue the development and optimization of assay suites for our current programs, and for the following research projects.
Have an extremely high level of organization, and the ability to maintain large volumes of data for the various DS and DP entities.
Demonstrate experience in developing, trouble shooting and running ELISA-type assays, including generation of the critical reagents, which includes generating high-affinity antibodies specific to the antigen and reviewing production protocols, requesting quotes, interacting with vendors, collecting and providing updates on production timelines.
Collaborate closely with external Vaxcyte Team members and to ensure supply/demand, DS and DP methods, CMO status and timelines are all in sync with assay development activities to hit milestones as needed.
Maintaining good laboratory practices, safety and record keeping for them-selves and their team is required.