Associate Scientist I, Small Scale Synthesis
About The Position
Arrowhead Pharmaceuticals, Inc. is a commercial stage biopharmaceutical company focused on developing medicines that treat intractable diseases by silencing the genes that cause them. They utilize a broad portfolio of RNA chemistries and efficient delivery methods to trigger the RNA interference (RNAi) mechanism, leading to rapid, deep, and durable knockdown of target genes. RNAi is a natural cellular mechanism that inhibits specific gene expression, thereby affecting protein production. Arrowhead's RNAi-based therapeutics leverage this pathway to address diseases with a genetic basis, typically characterized by the overproduction of disease-related proteins. Their versatile RNAi technologies allow them to target conditions in various therapeutic areas, including those not addressable by small molecules and biologics. Arrowhead is a leader in expanding RNAi applications beyond the liver, with a clinical pipeline targeting liver and lung diseases, and a promising preclinical pipeline. The company has corporate headquarters in Pasadena, CA, research and development teams in Madison, WI & San Diego, CA, and a manufacturing facility in Verona, WI. Employees are described as nimble, science-driven innovators collaborating to bring new therapies to patients. The Associate Scientist I will join the Discovery Chemistry Department, with primary responsibilities in oligonucleotide synthesis, purification, analytical chemistry, and contributing to specific program goals. This role involves working within a team of highly motivated and experienced scientists to contribute to the success of Arrowhead programs.
Requirements
- B.S. Chemistry or Biochemistry degree with excellent understanding of organic and analytical chemistry
- 0-2 years of experience working in a chemistry laboratory
- Experience with a wide range of analytical techniques, especially HPLC
- Ability to quickly learn new procedures and techniques
Nice To Haves
- Experience working with large molecule synthetic targets (especially oligonucleotides) either in an academic or industry setting
- Previous experience working in pharmaceutical setting
Responsibilities
- Maintain a well-documented laboratory notebook
- Track progress against project timelines, generate regular status updates, and communicate progress and issues to management
- Manage time effectively to meet deadlines
- Adhere to safe laboratory practices
- Perform synthesis, purification, and analysis of oligonucleotides
- Assist with maintenance of bioconjugate and oligonucleotide inventory
Benefits
- competitive salaries
- an excellent benefit package
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Entry Level
