Associate Scientist, Cell Signaling and Assay Development
About The Position
Reporting to the Director, Tissue or Assay / Laboratory Manager, the Associate Scientist will play a key role in the development, validation, and execution of live-cell assays supporting translational oncology research. This individual will contribute to advancing precision medicine by characterizing cell signaling pathways and ensuring the generation of high-quality, reproducible data in a high-complexity, CLIA-certified laboratory environment. Celcuity is a clinical-stage, publicly traded biotechnology company seeking to extend the lives of cancer patients through the development of targeted therapies for the treatment of multiple solid tumor indications. The company was founded to develop a better way to treat the cellular drivers of tumor growth. Our lead therapeutic candidate, gedatolisib, is an intravenously administered, potential first-in-class PI3K/AKT/mTOR (PAM) pathway inhibitor. Its mechanism of action and pharmacokinetic properties are highly differentiated from other currently approved and investigational therapies that target PI3K or mTOR alone or together. Gedatolisib phase 3 clinical development programs are focused on the treatment of patients with HR+/HER2- ABC in the 1L and 2L settings. A Phase 1b/2 clinical trial evaluating gedatolisib in combination with darolutamide in patients with metastatic castration resistant prostate cancer, is on-going. Celcuity is an Equal-Opportunity Employer. Celcuity is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are competitive. For this role, the anticipated base pay range is $90,000-$125,000 DOE. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.
Requirements
- Ph.D. in a relevant scientific discipline with experience in activity-based live-cell assay development for small molecules; OR Master’s degree with 5+ years of relevant industry experience; OR Bachelor’s degree in a scientific field with 6–8+ years of relevant industry experience.
- Hands-on experience with human cell culture techniques
- Experience with microplate-based live-cell assays
- Knowledge of multiparametric (e.g., 5-channel) cell cytometry
- Experience with immunochemistry techniques
- Strong understanding of laboratory quality systems, including QC, PM, and SOP adherence
Nice To Haves
- Experience with Jess (ProteinSimple) systems
- Experience working with human primary cells
Responsibilities
- Design, develop, validate, and transfer cell signaling and pathway-based assays across multiple cancer tissue types.
- Culture, maintain, and ensure consistency of human cell lines and primary samples under varied laboratory conditions.
- Perform phenotypic and pathway characterization using cell-based assays and integrate informatics data to identify and classify cell types.
- Adhere to CAP/CLIA standards and HIPAA regulations, maintaining compliance within a high-complexity clinical testing environment.
- Partner with Scientific Directors and laboratory leadership to troubleshoot assays, optimize protocols, and improve laboratory efficiency.
- Monitor and maintain quality control processes, including QC metrics, preventive maintenance (PM), and standard operating procedures (SOPs), ensuring data accuracy and reliability.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
