Associate Scientist, Biochemical Lead Profiling

Takeda • Boston, MA

3d

About The Position

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide. Objective / Purpose: Takeda’s Lead Profiling team is building a new team of experienced, innovative, and collaborative researchers to partner with Drug Discovery Units to design and run high throughput automated assays on state-of-the-art robotic platforms to drive an industry-leading portfolio of drugs for various Therapeutic areas with high unmet medical needs. We are seeking a skilled Associate Scientist to join the Lead Profiling and cross-functional discovery teams. Design and execute pre-clinical pharmacology assays on fully automated robotic platforms to support candidate selection, accelerating clinical translation of impactful therapies for patients with various disorders Provide hands-on expertise in the design and execution of miniaturized, high throughput assays to support programs across cross-functional teams Leverage state-of-the-art automation to streamline complex assay workflows and generate data to support various programs, in close collaboration with Takeda scientists and external partners Collaborate with multi-disciplinary team of drug discovery scientists that include Medicinal/Discovery Chemistry, Biology and Data Science to advance multiple small molecule programs as new clinical candidates for the treatment of various diseases. Design, optimize and execute biochemical screening assays including data analysis and interpretation. Optimize assays to support high throughput screening (HTS) and participate in screening hit validation and profiling using orthogonal biochemical assays. Ensure the timely execution of both HTS and IC50 determinations of profiling assays, and timely delivery of DMTA data to program teams. Interpret, summarize, and present research findings in internal working group meetings Maintain a stable and productive environment through Quality Control (QC), preventative maintenance (PM), and standard operating procedures (SOP). Demonstrate working knowledge of HTS automation platforms and associated assay technologies for lead-finding and follow-up activities. Demonstrate experience and understanding of HTS data analysis and software packages.

Requirements

• Master’s degree in Biochemistry, Cell Biology, Molecular Biology or related discipline with 3+ years OR Bachelor’s degree with 5+ years of relevant industry experience.
• Design and development of biochemical 384 and 1536-well plate-based assays (e.g., fluorescence, HTRF, FRET, bioluminescence assays, BRET etc.)
• Prior experience in small-molecule screening that includes familiarity with liquid handlers and automation systems is highly desirable
• Demonstrated ability to work independently and collaboratively to advance drug discovery projects in a highly matrixed environment
• Outstanding organizational skills and attention to detail
• Excellent cross-functional collaboration, communication, and interpersonal skills

Nice To Haves

• Proficiency in HTS automation is a plus
• Enzymology background preferred

Responsibilities

• Design and execute pre-clinical pharmacology assays on fully automated robotic platforms to support candidate selection, accelerating clinical translation of impactful therapies for patients with various disorders
• Provide hands-on expertise in the design and execution of miniaturized, high throughput assays to support programs across cross-functional teams
• Leverage state-of-the-art automation to streamline complex assay workflows and generate data to support various programs, in close collaboration with Takeda scientists and external partners
• Collaborate with multi-disciplinary team of drug discovery scientists that include Medicinal/Discovery Chemistry, Biology and Data Science to advance multiple small molecule programs as new clinical candidates for the treatment of various diseases.
• Design, optimize and execute biochemical screening assays including data analysis and interpretation.
• Optimize assays to support high throughput screening (HTS) and participate in screening hit validation and profiling using orthogonal biochemical assays.
• Ensure the timely execution of both HTS and IC50 determinations of profiling assays, and timely delivery of DMTA data to program teams.
• Interpret, summarize, and present research findings in internal working group meetings
• Maintain a stable and productive environment through Quality Control (QC), preventative maintenance (PM), and standard operating procedures (SOP).
• Demonstrate working knowledge of HTS automation platforms and associated assay technologies for lead-finding and follow-up activities.
• Demonstrate experience and understanding of HTS data analysis and software packages.

Benefits

• U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others.
• U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 5,001-10,000 employees