Associate Researcher I- Pharmacological Sciences
About The Position
The Associate Researcher I is a laboratory research position, responsible for independent conduct of routine and standardized experiments. This individual assists in the interpretation of research outcomes, performs assays to support research studies, and assists in the clerical and supply aspects of the laboratory environment. The candidate will join the Institute for Translational Immunology & Pharmacology at the Icahn School of Medicine at Mount Sinai as an Associate Researcher. The Associate Researcher will lead a flagship project entitled “De novo Design of First-in-Class Bifunctional Small Molecules for Precision Control of T-Cell Fate via Site-Specific p53 Modification”.
Requirements
- Bachelors or Masters degree in science or related field required
- No experience required.
Nice To Haves
- One year of research experience preferred.
Responsibilities
- Leading structure-based drug design using molecular docking, long-timescale molecular dynamics, free-energy perturbation (FEP), QM/MM, and AI-guided generative models for immunomodulatory compounds.
- Developing and applying deep-learning / diffusion models (AlphaFold-3, RFdiffusion, geometric DL) for de novo generation and multi-parameter optimization of novel chemical scaffolds.
- Performing or supervising multi-step organic synthesis of top-priority candidates, followed by full analytical characterization (NMR, LC-MS, HPLC).
- Driving rapid design–make–test–analyze (DMTA) cycles in collaboration with medicinal chemists and immunologists to validate target engagement, selectivity, and T-cell polarization activity in primary human and murine CD4⁺ T cells.
- Contributing to preclinical proof-of-concept studies, including dramatic prolongation of allograft survival and suppression of EAE through Treg/effector rebalancing.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Number of Employees
5,001-10,000 employees
