Associate Principal Scientist, Continuous & Expression Technologies (Downstream) - Onsite

MSD•Rahway, NJ

2d•Onsite

About The Position

The Continuous & Expression Technologies (CET) Group within the Process Research & Development, Enabling Technologies department is seeking motivated and creative individuals. This is an opportunity to positively impact our company’s manufacturing platforms, while actively supporting drug development in the biologics and vaccine arenas. Specifically, CET is seeking an Associate Principal Scientist specializing in bioprocessing purification technologies for multiple therapeutic classes – at our site in Rahway, NJ. Our Scientists are our Inventors. As a member of the CET Group, you will drive scientific innovation and critically evaluate opportunities to implement enabling technologies. We are seeking a collaborative, self-directed learner with a penchant for problem-solving and expertise in downstream bioprocessing to join the CET group. Our group is tasked with identifying, developing, and deploying continuous manufacturing tools aimed at improving production processes in our company's drug candidate pipeline. Knowledge of intensified unit operations such as multi-column chromatography, single-pass ultrafiltration and in-line diafiltration in addition to applied knowledge of hardware/software integration, process automation systems, and process analytical technologies (PAT) are valued skills within the group. Demonstrated expertise in process development, whether biologics, vaccines, or both, is particularly desirable. As an Associate Principal Scientist, you will have the opportunity to influence the future direction of our company's downstream processing for biologics. You will work with an immensely creative and collaborative team of scientists and engineers to design purification processes while developing technical strategies related to continuous processing and process intensification. As an experienced downstream scientist in the group, you will mentor and coach junior upstream scientists. The chosen candidate should also have excellent interpersonal communication and collaboration skills and exhibit strength in delivering results on firm deadlines. We actively publish and engage with the scientific community to influence the field.

Requirements

Ph.D. with 3+ years, MS with 5+ years, or BS with 8+ years of industry experience and background in Chemical/Biochemical engineering, or a related field
Strong fundamental knowledge and subject matter expertise in downstream process development
Experience in continuous biomanufacturing and experimentation with integrated purification steps
Expertise in independently conducting and directing the design, execution, analysis, and documentation of all stages of downstream process development
Track record of accomplishments in downstream bioprocessing with a history of peer-reviewed publications and presentations
Adaptability and agility to prioritize and deliver complex objectives, often on tight timelines, in a rapidly changing environment
Experience and aptitude to lead, work, and collaborate in internal and external cross-functional, matrixed teams
Action-oriented, mindset for creativity; ability to take initiative, innovate, iterate, and problem-solve
Demonstrated commitment to coach and mentor staff to maximize talent development and utilization
Excellent interpersonal and communication skills

Nice To Haves

Excellent interpersonal and communication skills
Experience with purification steps integrated with process-analytical technologies
High-throughput experimentation, automation, and process control
Experience with single-pass ultrafiltration and in-line diafiltration
Experience with high throughput experimentation using automation platforms such as TECAN
Experience using and/or programming process control systems such as DeltaV or PCS 7
Experience with multi-column chromatography systems (BioSMB, PCC, or similar)
Experience with statistical data analysis tools and design of experiments (JMP, Design Expert)
Experience with multivariate data analysis, machine learning, artificial intelligence
Experience with process modeling packages such as BioSolve Process, gPROMS, SuperPro Designer, or similar

Responsibilities

As an impactful contributor, shape and realize innovation across biologics’ pipeline, strategy, and science
Advance best science incorporation into pipeline by collaborating with cross-functional teams, from Research & Manufacturing, in a fast-paced, multidisciplinary environment
Lead development of robust and scalable technologies for downstream processes for biologics
Identify areas for downstream process innovation/intensification and expand our technologies toolbox to address challenges at different stages of development (clinical, process characterization and commercialization)
Contribute to strategic initiatives; partner with senior leaders to set overall project strategy, and guide teams towards its execution
Conceptualize, plan, and execute projects with effective organizational, prioritization and problem-solving skills
Stay abreast of scientific and regulatory landscape; actively present (premier conferences), publish (peer-reviewed journals) and patent
Serve as Subject Matter Expert for intensified and/or continuous bioprocessing
Mentor and actively share expertise; guide career development; build strong, collaborative teams

Benefits

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits.
Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days.
More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits

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