Associate Principal Scientist, Complex in Vitro Expert CVRI

Bayer Inc.•Cambridge, MA

48d•$114,846 - $172,270

About The Position

Bayer has an opening for an Associate Principal Scientist to join our Cardiovascular-Renal In Vitro Research group based at the Bayer Innovation Campus at the heart of Kendall Square in Cambridge, MA, with the goal to enhance internal expertise in the heart and kidney complex in vitro biology space. We are looking for a scientist with significant hands-on expertise in utilizing advanced cellular models, preferentially 3D organoid systems or organ-on-a-chip, to model cardiac and renal diseases in in vitro settings to enable the characterization of novel drug targets or therapeutic molecules. Specifically, the candidate will design and conduct experimental research studies at the bench, coach research associates, and propose therapeutics project(s) targeting cardiac or renal (including cardio-renal) disease. This is an excellent opportunity for a highly motivated candidate interested in exploring the early stages of drug development in a vibrant and collaborative atmosphere.

Requirements

Ph.D. in Biology (Cellular, Molecular or Developmental Biology), Biochemistry, or related life science field;
Background in cardiorenal disease biology;
In depth expertise and hands-on experience in stem cell biology and its translation to cardiovascular or renal disease modeling and drug discovery;
Hands-on experience in setting up complex in vitro models (organoids, spheroids, complex co-cultures, organ-on-a-chip) for disease modeling and profiling of drug candidates;
Strong expertise in relevant readouts (imaging, flow cytometry, protein and RNA analytical technologies) to characterize complex cellular model systems;
Track record of working on complex problems, and ability to integrate data from multiple disciplines;
Strong interpersonal, influencing, and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts;
Must demonstrate outstanding personal initiative, and accountability, communication skills, and the ability to work effectively as part of a team;
Ability to adapt, prioritize activities to and effectively manage changes in a fast paced and dynamic environment;
A passion for science and sense of urgency to find new medicines to benefit patients.

Nice To Haves

4+ years of relevant industrial research experience is preferred with a proven record of successful team leadership and interaction with collaborators.

Responsibilities

Responsible for identifying and setting up relevant complex in vitro models (3D organoid, organ-on-chip) to support cardiovascular and renal projects from target identification to preclinical candidate acceptance including hands-on experimentation, analysis of data and presentation to cross-functional project teams;
Support evaluation of external innovation landscape in the field of complex in vitro models and connection to external partners (CROs, academic partners);
Contribute to maintenance of human induced pluripotent stem cell cultures and differentiation into cells of interest (kidney organoids, cardiomyocytes);
Establish and provide guidance on QC and analytical protocols to enable a high degree of standardization of assay protocols;
Lead novel target proposals and experimental validation to support growth of our early cardiovascular & renal portfolio including presentation at internal governance;
Support BD&L assessment of external targets and programs to understand the competitive landscape and identify potential opportunities for collaboration or technological innovation;
Engage in close collaboration with scientists and technical staff of the Complex In Vitro Cluster based at the German sites to share knowledge, drive progress and stimulate innovation;
Prepare and update experimental protocols;
Independently perform data analysis and effectively interpret results;
Lead publication of results, prepare reports and presentations at both internal and external forums;
Coach research associates in a matrix organization;
Collaborate effectively with colleagues and interdisciplinary teams both within Bayer and with external collaborators;
Ensure that all tasks are in alignment with respect to HSE guidelines, documentation and good research practices.