Associate Manager, Screening and Compound Management

PTC Therapeutics, Inc. • Bridgewater, VT

3d

About The Position

The Associate Manager, Screening and Compound Management is integral to optimizing high-throughput screening robotic platforms and compound operations, directly supporting drug discovery initiatives. This role ensures the execution of high-quality biochemical and cell-based assays, overseeing vital processes such as compound handling, storage, and screening. By safeguarding the integrity of compound libraries and streamlining workflows, the Associate Manager accelerates research timelines and delivers essential data for early-stage drug development. As a part of a multidisciplinary team, the Associate Manager fosters a collaborative environment that champions innovation and continuous improvement through the development of methods for automated liquid handling systems and sophisticated data analytics tools. In addition to technical responsibilities, the Associate Manager participates in strategic planning and resource allocation to fulfill stakeholder needs, align compound management strategies with company’s broader research goals. This involves prioritizing screening campaigns, registering new chemical entities, and developing specialized protocols. Collaborating with teams in medicinal chemistry, biology, and research informatics, the Associate Manager ensures adaptability in a fast-paced research environment. The Associate Manager, Screening and Compound Management adheres to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.

Requirements

• Bachelor’s degree in chemistry, biology, biochemistry, or a related field with a minimum of 8 years of experience in compound management, high-throughput screening, or a related area within the pharmaceutical or biotechnology industry
• Proficiency in laboratory automation systems, liquid handling platforms, and data management tools.
• Familiarity with software systems such as LIMS (Laboratory Information Management Systems) (e.g. Scigilian, Dotmatics), automation systems (e.g.; Cellario and Strata) and cheminformatics platforms
• Solid understanding of assay development and optimization, along with the ability to troubleshoot technical challenges in a dynamic research environment.

Nice To Haves

• Master’s degree or Ph. D in biotechnology or a related scientific discipline is preferred.
• Hands-on experience in managing compound libraries, designing screening workflows, and utilizing automation technologies will be highly advantageous. For instance, experience in integrating robotic systems to streamline compound handling or implementing innovative screening technologies to improve efficiency will be considered a strong asset.
• Familiarity in traditional HTS assay detection methods including qPCR, Mesoscale, luminescence, FP, TR-FRET.
• Strategic mindset and a commitment to driving continuous improvement. Candidates should be adept at identifying emerging trends in screening technologies and compound management, leveraging these insights to advance innovation within the organization.
• Proactive approach to problem-solving and a focus on operational excellence will be key to success. Balancing technical expertise with strategic vision will enable the Associate Manager of Screening and Compound Management to make a significant impact on the organization’s research and development efforts.

Responsibilities

• Participate in strategic planning and execution of high-throughput screening campaigns, ensuring that all activities align with organizational goals and project timelines.
• Collaborate with cross-functional teams to design robust screening workflows, optimize assay conditions, and implement cutting-edge technologies to enhance data quality and throughput.
• Anticipate challenges, troubleshoot technical issues, and adapt strategies will be critical in maintaining the efficiency and reliability of screening operations.
• Provide detailed reports and analyses of screening outcomes, ensuring that findings are effectively communicated to stakeholders and integrated into broader research initiatives.
• Manage the compound library, a cornerstone of the organization’s research and development efforts.
• Implement advanced inventory management systems and maintain quality control protocols.
• Work closely with medicinal chemistry teams to expand the library while maintaining compliance with regulatory and safety standards.
• Execute strategies to optimize compound storage conditions and ensure long-term stability, safeguarding the organization’s investment in its chemical assets.
• Drive continuous improvement initiatives to enhance the efficiency and impact of screening and compound management processes.

Benefits

• In addition to base salary, PTC employees are also eligible for short- and long-term incentives.
• All eligible employees may also enroll in PTC’s medical, dental, vision, and retirement savings plans.

What This Job Offers

• Job Type: Full-time
• Career Level: Manager
• Number of Employees: 501-1,000 employees