Associate Director - Protein Engineering and Production

AstraZeneca • Waltham, MA

2d

About The Position

Associate Director - Protein Engineering and Production Introduction to Role: Are you a proven leader ready to drive the future of protein production in the biopharma space? We are seeking an Associate Director to lead our Protein Engineering and Production team, with a strong focus on large-scale, multi-specific antibody therapeutics. In this role, you’ll oversee a high-performing team of scientists, collaborate across multi-disciplinary engineering groups, and help shape the evolution of automated, high-throughput workflows. We’re looking for someone who brings production leadership, scientific rigor, and a passion for operational excellence. Bonus if you bring an understanding of automation technologies or have led automation-driven innovation in production settings. Accountabilities: Lead, manage, and mentor a production-focused team of scientists in a high-throughput, fast-paced environment. Provide strong leadership with an emphasis on team development, scientific excellence, and delivery on production goals. Collaborate cross-functionally with automation engineers, software developers, and scientific teams to optimize and scale production processes. Oversee design and execution of protein expression and purification workflows, integrating automation to improve throughput and quality. Ensure scientific robustness in production of multispecific antibody formats, with a focus on timelines and operational efficiency. Present complex data and strategic updates to senior leadership and cross-functional stakeholders. Drive continuous improvement through workflow optimization, problem-solving, and technological innovation.

Requirements

• PhD in Biotechnology, Molecular Biology, Biochemistry, or related field with 5+ years of post-degree experience in protein production or engineering. (Master’s with 10+ years, or Bachelor’s with 15+ years will also be considered.)
• Proven leadership experience, preferably with direct people management and oversight of a production or operations team.
• Deep expertise in molecular biology, cloning, expression, and purification of therapeutic proteins.
• Demonstrated experience working in or with multi-disciplinary engineering teams (e.g., automation, software, bioengineering).
• Hands-on experience with automated liquid handling systems (e.g., Hamilton, Lynx).
• Excellent problem-solving abilities and familiarity with high-throughput technologies.
• Strong organizational and project management skills; proven ability to drive timelines and deliverables.
• Excellent communication skills; able to translate complex science into actionable plans and presentations.

Nice To Haves

• Experience developing or optimizing automated workflows and using scheduling software (e.g., Green Button Go).
• Familiarity with Python, Jupyter notebooks, or data analysis tools.
• Experience with CHO or HEK293 cell lines and tissue culture.
• Exposure to design of experiments (DoE) for process optimization.
• Background in antibody discovery, imaging, or flow cytometry (iQue, FlowJo, Attune).
• Track record of scientific publications, patents, or conference presentations.

Responsibilities

• Lead, manage, and mentor a production-focused team of scientists in a high-throughput, fast-paced environment.
• Provide strong leadership with an emphasis on team development, scientific excellence, and delivery on production goals.
• Collaborate cross-functionally with automation engineers, software developers, and scientific teams to optimize and scale production processes.
• Oversee design and execution of protein expression and purification workflows, integrating automation to improve throughput and quality.
• Ensure scientific robustness in production of multispecific antibody formats, with a focus on timelines and operational efficiency.
• Present complex data and strategic updates to senior leadership and cross-functional stakeholders.
• Drive continuous improvement through workflow optimization, problem-solving, and technological innovation.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree