Associate Director, Portfolio Analytics

Flagship Pioneering, Inc. • Cambridge, MA

66d • $148,000 - $203,500

About The Position

The Associate Director of Portfolio Business Analytics is a key contributor of Product and Partnering organization, a Flagship Pioneering initiative focused on conceiving and developing transformative treatments for patients. We build a portfolio of novel therapeutics by harnessing Flagship’s scientific platforms and applying them to serious diseases beyond their current focus areas. Through this approach, we aim to bring the benefits of Flagship’s innovation to more patients, faster. This role sits at the intersection of science, strategy, and finance—supporting portfolio decision-making through rigorous analytics, financial modeling, and market evaluation. The successful candidate will combine deep biopharma industry knowledge with advanced financial modeling skills, particularly in valuation and forecasting of pharmaceutical products across therapeutic areas and development stages. The individual will collaborate across R&D, business development, finance, and commercial strategy teams to generate data-driven insights that inform portfolio and investment decisions.

Requirements

• Ph.D. in a life science discipline (e.g., Biology, Biomedicine, Chemistry, Pharmacology) with at least 3 years of relevant industry or consulting experience.
• MBA with a strong quantitative or finance focus (e.g., healthcare management, finance, strategy) with at least 5 years of relevant experience.
• Master’s degree in life sciences, economics, finance, or a related field with at least 5 years of experience.
• Bachelor’s degree in life sciences, economics, finance, or a related field with at least 8 years of relevant experience.
• Demonstrated expertise in financial modeling and valuation of pharmaceutical assets and portfolios, including revenue forecasting and risk-adjusted returns.
• Experience in biopharma investment banking, Big 4 advisory, life science strategy consulting, or corporate/business development in biotech or pharma.
• Proven ability to perform competitive analysis and market assessments across therapeutic areas.
• Familiarity with analytics and forecasting tools, such as advanced Excel modeling.
• Experience with Tableau, Power BI, or equivalent visualization platforms and portfolio management or valuation software (e.g., Planisware, Palantir) is a plus.
• Strong analytical, critical thinking, and problem-solving skills with the ability to synthesize complex data into actionable insights.
• Excellent written communication skills, including experience preparing executive-ready materials and analyses to support senior decision-making.
• Ability to work effectively in a cross-functional, fast-paced, and entrepreneurial environment, managing multiple priorities under tight deadlines.
• Collaborative team player with strong interpersonal skills and the ability to influence without authority.

Responsibilities

• Develop robust, detailed financial models for Flagship’s therapeutic programs and platforms, including revenue forecasts, valuation analyses (DCF, NPV, rNPV), and scenario planning.
• Translate scientific, clinical, and operational assumptions into quantitative business models.
• Support capital allocation analyses and portfolio prioritization through rigorous sensitivity and risk-adjusted analyses.
• Maintain and improve financial models and forecasting frameworks as portfolio complexity increases.
• Conduct comprehensive market landscape analyses using both secondary sources and primary research (e.g., KOL interviews, surveys) to assess unmet needs, competitive dynamics, and market potential.
• Monitor key trends in relevant therapeutic areas and biopharma markets to inform portfolio strategy.
• Understand competitive positioning of ongoing and planned Pioneering Medicines programs.
• Summarize market and competitor insights into clear, concise reports for leadership review.
• Build and maintain portfolio analytics tools and frameworks to support resource planning, portfolio valuation, and scenario modeling.
• Prepare high-quality materials and analyses for internal governance and investment committee reviews, including portfolio summaries, risk assessments, and valuation comparisons.
• Ensure consistent use of financial and operational metrics across programs and functions.
• Benchmark portfolio and organizational performance against comparable biotech and pharma peers to identify key measures of success.
• Partner closely with R&D, Competitive intelligence, Finance, Business Development, and Commercial Strategy teams to align scientific and business perspectives in portfolio analytics.
• Collaborate with data and insights teams to integrate forecasting models with relevant clinical and operational data systems.
• Serve as an analytical partner to program leads, helping teams understand value drivers, risks, and key decision points.
• Collaborate with Finance on annual LRP process and output.
• Lead cross-functional analytical initiatives.
• Proactively identify analytical or process improvements to enhance portfolio visibility and decision-making.
• Champion data-driven and enterprise-level thinking across Pioneering Medicines teams.
• Build scalable systems and dashboards to enable efficient portfolio tracking and forecasting.
• Drive standardization of assumptions, metrics, and templates across portfolio analyses.
• Complete ad hoc requests and deliver outputs with minimal oversight in a timely manner.

Benefits

• healthcare coverage
• annual incentive program
• retirement benefits
• broad range of other benefits

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree
• Number of Employees: 251-500 employees