Associate Director, Pharmacometrician
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About The Position
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. We are seeking a passionate and energetic individual with strong PKPD modeling background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization. As a PKPD modeler to support the pharmacometrics functions in the department, you will establish population PK models to identify intrinsic and extrinsic factors that impact PK, and to guide dose/schedule optimization and recommended phase 2 dose/schedule (RP2Ds) selection. You will perform model-based simulations to optimize dosing to inform trial designs and clinical outcomes, ensuring quality and integrity of modeling and simulation results. Additionally, you will author and provide technical input for regulatory documents and submissions related to all aspects of pharmacometrics and engage with consultants and/or CROs on pharmacometrics activities to complement in-house knowledge/expertise and capacities.
