Moderna Theraputics-posted 2 months ago
Full-time • Mid Level
Remote • Massachusetts, MA
5,001-10,000 employees
Professional, Scientific, and Technical Services

Moderna is seeking a Translational Medicine Scientist to play a pivotal role in bridging the gap between preclinical research and clinical application to accelerate the development of groundbreaking therapies. This Translational Medicine role is focusing on next generation mRNA therapeutics in Oncology. The role will work with a cross functional team (medical directors, nonclinical and discovery research scientists, regulatory, clinical operations, biostatisticians, bioinformaticians and clinical pharmacologists) to develop translational strategies and help oversee the execution of these strategies for pre-clinical and clinical stage assets. Position is ideally based in Cambridge, MA headquarters.

  • Work across Research and Development to define translational medicine strategy for oncology assets, including making recommendations regarding indications, endpoints, study design, safety evaluations and dose selection.
  • Identify and seek to validate novel endpoints for early (pre-POC) decision making and identify patient or target population stratification strategies to support rapid demonstration of safety and efficacy.
  • Develop and lead reverse translational strategy to further inform research and development.
  • Work closely with other matrix functional areas to define key aspects of the integrated development plans, including the assessment of medical need, proposal of clinical development pathways, and review of preclinical data for clinical implications.
  • Collaborate with Biomarkers Lead(s) to define strategy for clinical stage programs, including design and writing, as well as authoring the biomarker sections of Investigator Brochures, Clinical Study Protocols and Reports, program documents, regulatory submissions, and responses (INDs/CTAs) as well as co-authoring, assisting, and supporting the development of publications, abstracts, and presentations.
  • Partner with biostatisticians and biomarker experts to ensure high-quality data to support analysis, interpretation, and reports for internal decision-making.
  • Works with program team leads to ensure efficient implementation of all key deliverables and provides frequent project status updates to the cross-functional development teams.
  • Advanced scientific degree in a relevant scientific field (Ph.D., Pharm.D. or MD) preferred, with minimum 5 years of relevant work experience developing biomarker and translational medicine strategies.
  • A strong background in Oncology, Immunology, and experience in translational medicine.
  • Proficiency in emerging diagnostic and predictive biomarker technologies is a plus.
  • Innovative problem-solving skills with a focus on complex scientific challenges.
  • Advanced communication skills for effective negotiation and stakeholder engagement.
  • Demonstrated track record in leading cross-functional teams and work streams (e.g., translational medicine, biostatistics, regulatory, pharmacology, clinical and immunogenicity assay development).
  • Understanding of the entire Oncology development process, including clinical and non-clinical study design, use of immunologic surrogates, assay development and importance of target product profile.
  • Best-in-class healthcare coverage, plus a suite of voluntary benefit programs to support your unique needs.
  • A holistic approach to well-being, with access to fitness, mindfulness, and mental health support.
  • Lifestyle Spending Accounts to personalize your well-being journey.
  • Family planning and adoption benefits.
  • Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown.
  • Savings and investment opportunities.
  • Location-specific perks and extras.
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