Recursion-posted about 2 months ago
$163,800 - $192,400/Yr
Full-time • Director
Hybrid • Salt Lake City, UT
501-1,000 employees

Your work will change lives. Including your own. The Impact You’ll Make Recursion is on the cutting edge of drug discovery, generating proprietary maps of biology that provide unique insights, driving target identification, validation, and ultimately novel clinical candidates. We are seeking an Associate Director, CMC Drug Substance to advance our current and future clinical assets through development and ultimately to patients in need. In this role, you will: Lead external drug substance development across our portfolio including oversight of CDMOs and strategic technical development relationships Provide technical leadership, project management and oversight of drug substance process development and manufacturing activities supporting Recursion’s clinical programs Ensure delivery of drug substance from external manufacturing campaigns adhering to current quality guidelines and delivery timelines. Typical travel to external manufacturing sites is 10-20% of the time. Critically analyze process and analytical data to identify and resolve key synthetic challenges during drug substance development Participate in developing and extending our CDMO relationships, budget planning and forecasting for drug substance expenditures and achieving our quality requirements The Team You’ll Join As Associate Director, CMC Drug Substance, you will be an essential member of the Recursion CMC Team reporting to the Executive Director, CMC Drug Substance. The CMC Team is an empowered, execution-minded group of scientists and technical experts responsible for translating Recursion’s innovative science to patients in clinic through CMC activities and deliverables.

  • Lead external drug substance development across our portfolio including oversight of CDMOs and strategic technical development relationships
  • Provide technical leadership, project management and oversight of drug substance process development and manufacturing activities supporting Recursion’s clinical programs
  • Ensure delivery of drug substance from external manufacturing campaigns adhering to current quality guidelines and delivery timelines. Typical travel to external manufacturing sites is 10-20% of the time.
  • Critically analyze process and analytical data to identify and resolve key synthetic challenges during drug substance development
  • Participate in developing and extending our CDMO relationships, budget planning and forecasting for drug substance expenditures and achieving our quality requirements
  • Ph.D. in organic chemistry or closely related field with a minimum of 5-8 years experience or M.S. with 8-12 years of experience
  • Strong knowledge and experience in small molecule drug substance process development and manufacturing best practices across all phases of drug development, from initial regulatory filings through registration, validation and launch
  • Demonstration of cross-functional understanding related to drug substance development including salt/polymorph screening, phase appropriate analytical development, standard process of drug product development, quality and regulatory affairs
  • Well-versed in the latest trends impacting drug substance technology, manufacturing and the outsourcing industry
  • Prior experience leading external development and CDMO relationships is a plus
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