Associate Director, Analytical Chemistry

Revolution Medicines•Redwood City, CA

4h•Hybrid

About The Position

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. Revolution Medicines is seeking a scientifically talented and motivated individual to join our Integrated Discovery Research team as Associate Director, Analytical Chemistry. This role will drive analytical chemistry efforts within the Medicinal Chemistry function and collaborate cross-functionally to support our drug discovery programs from early hit identification through lead optimization and candidate selection. Reporting to the Director of Medicinal Chemistry, this position offers a unique opportunity to shape analytical science at the frontiers of small molecule beyond Rule-of-Five (bRo5) drug discovery.

Requirements

Ph.D. in Analytical or Organic Chemistry (or related discipline) with 5+ years of industry experience, or M.S. with 10+ years of relevant experience.
Demonstrated success in analytical method development, troubleshooting and problem-solving for small molecule drug discovery.
Strong hands-on knowledge of chromatographic and spectroscopic techniques, including LC/MS, HPLC, and SFC.
Strong leadership and people management capabilities with a collaborative, mentoring mindset.
Strong problem-solving skills with sound technically driven decision-making ability.
Excellent communication skills and the ability to drive cross-disciplinary partnerships.
A track record of innovation and execution in fast-paced, data-driven research environments.

Nice To Haves

Experience supporting beyond Rule-of-Five (bRo5) medicinal chemistry, including macrocycles, covalent inhibitors, or other alternative modalities.
Ability to integrate analytical insights into medicinal chemistry decision-making.
Working knowledge of lab automation and high-throughput analytical techniques.
Experience with advanced NMR spectroscopy.

Responsibilities

Lead and manage analytical chemistry strategy and daily operations to support small molecule drug discovery programs across multiple stages.
Develop and implement robust analytical methods (e.g., LC/MS, HPLC, SFC) for compound characterization, purity assessment (including chiral purity), and stability or reactivity studies (e.g. GSH assay).
Manage and execute compound purification (including chiral separations), structural elucidation, and physicochemical property assessment in the beyond Rule-of-Five chemical space.
Collaborate closely with medicinal chemists, process chemists, DMPK scientists, and manage external analytical chemistry service providers to ensure timely and high-quality analytical data.
Lead and mentor a team of analytical chemists, fostering scientific excellence and professional development.
Collaborate closely with LabOS team, Data Sciences and Data Analytics functions to develop and implement automated high-throughput analytical methods that enhance efficiency and data quality.
Ensure compliance with safety standards in laboratory operations.
Contribute to invention disclosures, patent filings, and external scientific publications as appropriate.