Analytical Chemist

Techtrueup • Boston, MA

7h • Hybrid

About The Position

The Analytical Chemist will join client's growing Technical Operations Analytical team and has the primary responsibility to provide analytical support for Oligonucleotides and Peptides in late-stage phase.

Requirements

• BS or MS degree in Chemistry, Analytical Chemistry, or related field with 3+ years of relevant industry experience.
• Strong experience in analytical method development, optimization, transfer, and validation for oligonucleotide therapeutics.
• In-depth knowledge of mass spectrometry and purification techniques.
• Hands-on expertise in RP-HPLC, SAX-HPLC, UPLC, LC-MS, and related analytical platforms.
• Working knowledge of cGMP regulations and documentation practices.
• Strong technical writing, problem-solving, and cross-functional collaboration skills.

Responsibilities

• Provide analytical support for oligonucleotide and peptide–oligonucleotide conjugated compounds in late-stage development.
• Develop, optimize, and validate robust LC/MS, IP-RP-HPLC, and SAX-HPLC analytical methods for the analysis and purification of highly modified oligonucleotide drug substances.
• Perform analytical testing using IP-RP-HPLC, AX-HPLC, UPLC, LC-MS, and LC-MS/MS systems (Agilent, Waters, Thermo) and associated data software.
• Operate, maintain, and troubleshoot laboratory instrumentation to ensure accurate and reliable results.
• Ensure compliance with GLP/GMP standards in a regulated pharmaceutical environment.
• Author technical documents including protocols, reports, and method validation documents; effectively communicate findings across cross-functional teams.
• Work independently while collaborating with Technical Operations, Quality, and Manufacturing teams.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level