Analytical Chemist II

Bureau Veritas•Indianapolis, IN

3d•$28 - $31

About The Position

The Analytical Chemist II is responsible for supporting oligonucleotide analysis portfolio and delivering analytical quality management. Analytical instruments including AKTA, LC-MS, HPLC/UPLC, LTQ, QDA, CAD, Circular Dichroism, Karl Fischer titration, UV-Vis/Fluorescence spectrophotometer, TFF, thermal cycler, Nanodrop, SoloVPE along with automation integration systems will be used on a routine basis.

Requirements

Experience, troubleshooting, and optimizing synthetic protocols on various synthesizers
Strong laboratory skills and experience with analytical instrumentation such as AKTA, Agilent LC-MS and UPLC, Vanquish LTQ, Water’s QDA, etc.
Experience in developing new chromatographic methods (IEX/RP-HPLC, SPE, LC-MS).
Strong organizational skills and ability to prepare written technical reports
Strong oral communication skills in presenting facts and recommendations
Confident, execution-focused, and team oriented with a desire to thrive in a fast-paced growing environment
Written and verbal communication skills including the ability to communicate effectively in a group setting, with colleagues and clients
Ability to perform multiple tasks
Ability to organize and prioritize workload to meet or exceed deadlines
Individual and Team work ethic
Proficiency with Windows, Word & Excel
Attention to detail
Positive attitude, self-motivated, high level of engagement
Champions and adheres to company values including team engagement
Degree requirement: Bachelor's Degree in Chemistry, Biochemistry, or closely related field
One (1) year of experience with oligonucleotide chemistry helpful
An equivalent combination of education and experience may be accepted in lieu of above

Responsibilities

Perform precise and accurate sample preparation, including weighing, diluting, extraction and purifying samples for various analytical techniques.
Develop, validate and document standard operating procedures for sample handling, ensuring consistency and repeatability in all preparation activities.
Maintain detailed records and logs of all sample preparation steps, calculations and observations, supporting data integrity and traceability
Collect, record and organize experimental data, conduct basic analyses to interpret results and support ongoing laboratory research
Use of general laboratory equipment including but not limited to pipettors, centrifuges, incubators, biological safety cabinets and balances
Perform RNA Sample preparation and gel electrophoresis
Follow instruction and perform instrumental analysis on instruments including but not limited to AKTA, LC-MS, HPLC/UPLC, LTQ, QDA, CAD, Circular Dichroism, Karl Fischer titration, UV-vis/ Fluorescence spectrophotometers, thermal cycler, Nanodrop, SoloVPE instruments, etc. Provide basic troubleshooting to mentioned instrument.
Instrument maintenance - MS and LC (pressure, column, etc) and troubleshooting LC/MS issues as they arise
Work closely with members of the RNAi chemistry team to understand and validate requirements for oligonucleotide analytical control.
Hands-on and independent lab experience with concentration calculation and unit conversion, buffer preparation, solution preparation, separation, quantification of DNA/RNA, oligonucleotides, etc.
Software includes instrument-specific for capturing and analyzing data, Microsoft Office (Word, Excel, PowerPoint, Outlook, Teams/SharePoint, GraphPad Prism, Spotfire, etc), LIMS, electronic laboratory notebooks, etc.
Detailed record keeping of daily experiments in ELNs
General lab maintenance and Inventory management
Follow the guidelines set forth with clients and Company Quality, Health, Safety, Security and Environmental policies and procedures.
Comply with clients’ and Company management systems in accordance with appropriate regulatory agencies.
Perform other essential tasks projects and responsibilities as required.
Other duties as defined by the Manager, department needs and workload