Advisor - Scientific Lead - Computational Chemistry, Advanced Molecular Design
About The Position
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Overview: At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism. The Lilly Small Molecule Discovery group is an organization purpose-built to create molecules that make life b etter for people. We focus on using cutting edge science to unlock new approaches that can treat people suffering from diseases with poor treatment options. We continually challenge ourselves to deliver molecules that can provide breakthrough efficacy with the highest possible safety margins. We are dedicated to optimizing our mindset, technology, and processes for faster, more nimble execution. Our success is built on a culture that empowers innovative problem solving through open collaboration and individual accountability. Position Summary: Lilly’s Advanced Molecular Design (AMD) team is responsible for small molecule lead optimization with rapid pr ogress tow ard new clinical candidate s for patien ts in need . We are currently looking for an early career scientist dedicated to applying cutting edge computational chemistry tools in our close collaborative efforts with our colleagues across medicinal chemistry and structural biology . The ideal candidate will be passionat e about a holistic approach to drug discovery , where all aspects of molecular design are considered and thoughtfully anticipated up to and including clinical trials . Interactive communication and interpersonal collaboration will be essential to successfully fulfilling this important role in Lilly S mall M olecule D iscovery.
Requirements
- PhD with 0 to 5 years of Drug Discovery research experience
Nice To Haves
- A scientific background in computational chemistry and related technology applied to guide compound optimization for medicinal chemists
- Proactive and effective collaborat ion with medicinal chemist ry , structural biolog y , and other disciplines to achieve project goals and timelines
- Strong core desire to help patients in need
- Deep-thinking that leads to creative hypotheses for the optimization of lead series across multiple projects
- A strong desire to es tablish a deeper underst anding of all aspects of drug discovery, including small molecule-protein interactions, ADME, and toxicological considerations
- A desire to continually stay up to date with the latest industry developments and novel techniques employed in discovery including AI and machine learning models
- A proactive and highly engaged approach to solving challenging problems in discovery is essential
- Knowledge of lead optimization using structure-based design and other aspects of computational chemistry
- Agility and adaptability to change research priorities as necessary for success
Responsibilities
- S tructure -based design efforts for the lead/late-stage optimization of small molecule therapeutics across a range of therapeutic areas
- Play a key role in prioritizing medicinal chemistry efforts through critical analysis and effective decision-making leading to highly focused work and rapid progress
- Ensure the timely delivery of data and results to project teams to enable rapid iterative design cycles
- Maintain critical timelines and set team expectations for efficient deliver y of clinical candidates
- Work closely with other discovery scientist s to move our portfolio of molecules from leads to quality drug candidates that have a strong potential to become breakthrough drugs
Benefits
- Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
