2026 Summer Intern - Genetic Medicine Technology: Precision Gene Editing Team

Genentech • San Diego, CA

35d • $23 - $44 • Onsite

About The Position

The newly formed Genetic Medicine Technology group in gRED (Genentech Research and Early Development) is redefining the future of cell and gene therapies. Our proprietary non-viral gene delivery and gene editing platforms serve as a versatile foundation for a wide range of therapeutic modalities, with potential applications extending across a broad spectrum of oncology and genetic diseases. We are committed to building a world-class organization that bridges the gap between early-stage technology discovery and life-changing clinical applications. Within this group, the Precision Gene Editing team focuses on the engineering and optimization of next-generation genome editing technologies. Our team’s mission is to discover and develop novel enzymes—including transposases, recombinases, and CRISPR-associated nucleases—to enhance the efficiency and safety of DNA manipulation for our proprietary gene insertion platforms. By integrating rational design, structure-guided computational methods, and directed evolution, we are building a sophisticated protein engineering toolbox designed to manipulate mammalian genomes with unprecedented efficiency and specificity. This internship position is located in San Diego, CA, on-site.

Requirements

• Must be pursuing a Bachelor's Degree (enrolled student).
• Must have attained a Bachelor's Degree (not currently enrolled in a graduate program).
• Must be pursuing a Master's Degree (enrolled student).
• Must have attained a Master's Degree.
• Must be pursuing a PhD (enrolled student).
• Molecular/Cell Biology, Biological/Biomedical Engineering, Biochemistry, Bioinformatics, or a r elated scientific field.
• Proficiency in core molecular biology (cloning, PCR) and familiarity with genome editing technologies (CRISPR, piggyBac, recombinases).
• Hands-on experience with mammalian cell culture, transfection, and functional cell-based assays.
• Understanding of protein engineering techniques (e.g., rational design, directed evolution, library design).
• Strong attention to detail with a proven track record of maintaining precise experimental records (Electronic Lab Notebooks) and performing basic data analysis.

Nice To Haves

• Experience with ddPCR for genomic quantification and/or Flow Cytometry for fluorescent reporter expression.
• Familiarity with programming languages (Python or R) for biological data analysis or software for structural protein modeling (e.g., PyMOL, AlphaFold, Rosetta).
• Excellent communication, collaboration, and interpersonal skills.
• Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.

Responsibilities

• Support the design and construction of enzyme variants using molecular biology techniques such as Gibson Assembly, Golden Gate cloning, and site-directed mutagenesis.
• Assist in routine molecular biology tasks, including PCR, restriction digestion, plasmid DNA purification (mini/maxi-preps), and sequence verification to support the iterative building of transposase variants.
• Utilize non-viral delivery methods, including nucleofection and other transfection techniques, to introduce novel gene-insertion tools (transposases, recombinases, or nucleases) into mammalian cell lines and execute cell-based assays to evaluate their efficiency.
• Perform standard analytical assays—such as ddPCR for copy number determination or flow cytometry—to characterize the performance of engineered transposase candidates.
• Utilize computational tools and structural biology data to analyze experimental results, helping to refine design strategies and predict the performance of engineered protein variants.

Benefits

• Intensive 12-week, full-time (40 hours per week) paid internship.
• Program start dates are in May/June 2026.
• A stipend, based on location, will be provided to help alleviate costs associated with the internship.
• Ownership of challenging and impactful business-critical projects.
• Work with some of the most talented people in the biotechnology industry.
• paid holiday time off benefits

What This Job Offers

• Job Type: Full-time
• Career Level: Intern
• Number of Employees: 5,001-10,000 employees