2026 Summer Intern - Clinical Pharmacology

Roche•South San Francisco, CA

8d•$50 - $50•Onsite

About The Position

Clinical Pharmacology is a dynamic function that plays a critical role in supporting drug development teams and in optimizing the dosing regimen for patients. Utilizing our expertise in pharmacokinetics and pharmacodynamics, Clinical Pharmacologists contribute at every stage of development, applying quantitative pharmacology principles across a molecule's life-cycle for both small molecules, biologics, and novel treatment modalities. The Clinical Pharmacology department is instrumental in shaping future treatments and ensuring they are both safe and effective. This internship position is located in South San Francisco, on-site. The key responsibilities may include, but are not limited to: Conduct systematic reviews of relevant scientific literature and regulatory documents (e.g., FDA/BLA/NDA submissions) to identify and extract critical information. Develop, validate, and apply mechanistic Physiologically-Based Pharmacokinetic (PBPK) models, with a particular focus on Physiologically-Based Biopharmaceutics Models (PBBM), to address Clinical Pharmacology questions such as the impact of food, proton pump inhibitors (PPIs), and formulation changes on pharmacokinetics. Formulate scientifically sound conclusions and present the research outcomes internally and externally. Intensive 12-weeks, full-time (40 hours per week) paid internship. Program start dates are in May/June 2026. A stipend, based on location, will be provided to help alleviate costs associated with the internship. Ownership of challenging and impactful business-critical projects. Work with some of the most talented people in the biotechnology industry.

Requirements

Required Education: You meet one of the following criteria: Must be pursuing a Master's Degree (enrolled student). Must have attained a Master's Degree. Must be pursuing a PhD (enrolled student).
Required Majors: Pharmacokinetics, Pharmaceutics, or other quantitative disciplines (Statistics/Biostatistics, Computational Biology/Chemistry, Chemical/Biomedical Engineering).
Required Skills: Foundational knowledge and experience in pharmacokinetics and ADME of small molecules. Experience with PBPK modeling; familiarity with Simcyp and/or MATLAB is strongly preferred.

Nice To Haves

Excellent communication, collaboration, and interpersonal skills.
Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.

Responsibilities

Conduct systematic reviews of relevant scientific literature and regulatory documents (e.g., FDA/BLA/NDA submissions) to identify and extract critical information.
Develop, validate, and apply mechanistic Physiologically-Based Pharmacokinetic (PBPK) models, with a particular focus on Physiologically-Based Biopharmaceutics Models (PBBM), to address Clinical Pharmacology questions such as the impact of food, proton pump inhibitors (PPIs), and formulation changes on pharmacokinetics.
Formulate scientifically sound conclusions and present the research outcomes internally and externally.