Sr. Scientist II, Research Production Core

Scribe Therapeutics is seeking a highly motivated individual to join their team as a Sr. Scientist II. The role involves direct high-throughput production screening of viral vectors, managing upstream cell culture and vector production, and supporting development activities for gene editing therapeutics. The candidate should have excellent communication skills, be a team player, and have the ability to meet project timelines in a fast-paced environment. This position offers opportunities for professional growth and the potential to take on leadership responsibilities.

• Direct high-throughput production screening of research grade viral vectors (AAV and LV) from upstream cell culture, downstream purification, QC testing, and assay development to drive Discovery activities and delivery of Scribe's Cas nucleases for therapeutic pipeline programs
• Manage routine upstream cell culture and vector production, as well as downstream purification operations to produce viral vectors
• Motivated to learn new modalities to support the various delivery options for gene editing therapeutics (including mRNA and LNP technologies)
• Act as a scientific liaison for CMC assay development support of early-stage programs
• Excellent communication and presentation skills, capable of conveying complex technical information and experimental results and plans in a clear, concise, and influential manner to relevant cross-functional teams
• Must be a team player, strong critical thinker, exhibit a willingness to meet project timelines and multitask effectively in a dynamic fast-paced environment under challenging timelines
• Develop procedures and documentation to successfully perform specific unit operations in the production of viral vectors
• Maintain operations and personnel scheduling, oversee vector lab organization, inventory, and equipment maintenance, and fulfill other required duties for continuous production operations
• Maintain scientific and technical expertise through familiarity with scientific literature and developing relationships with thought leaders
• Manage one or more Research Associates
• MS with 10+ years of relevant experience, or BS with 12+ years of relevant experience in biochemistry, bioengineering, chemical engineering, virology, or related field in an academic or industry lab
• Solid proficiency in common biochemical and molecular techniques

• MS with 10+ years of relevant experience, or BS with 12+ years of relevant experience in biochemistry, bioengineering, chemical engineering, virology, or related field in an academic or industry lab
• Direct high-throughput production screening of research grade viral vectors (AAV and LV) from upstream cell culture, downstream purification, QC testing, and assay development
• Manage routine upstream cell culture and vector production, as well as downstream purification operations to produce viral vectors
• Motivated to learn new modalities to support the various delivery options for gene editing therapeutics (including mRNA and LNP technologies)
• Prior knowledge in analytical method development to act as a scientific liaison for CMC assay development support of early-stage programs
• Excellent communication and presentation skills
• Must be a team player, strong critical thinker, exhibit a willingness to meet project timelines and multitask effectively in a dynamic fast-paced environment under challenging timelines
• Develop procedures and documentation to successfully perform specific unit operations in the production of viral vectors
• Maintain operations and personnel scheduling, oversee vector lab organization, inventory, and equipment maintenance
• Maintain scientific and technical expertise through familiarity with scientific literature and developing relationships with thought leaders
• Strong critical thinking skills, capable of meeting project timelines and multitasking effectively
• Experience managing one or more Research Associates

• Comprehensive medical and other benefits
• Salary commensurate with experience
• Intellectually stimulating and fast-paced environment
• Equal opportunity employer
• Base pay wage range of $140,000-185,000 per year
• Additional incentives provided as part of the complete package
• Collegial and collaborative atmosphere
• Opportunity to work with CRISPR technologies
• Opportunity to work in or lead a Vector Core or process development
• Opportunity to work with mRNA production and chromatography
• Opportunity for career growth and development
• Opportunity to work with advanced analytical techniques
• Opportunity to work with scientific literature and thought leaders
• Opportunity for people management experience
• Opportunity to work with various software programs (JMP and DoE, Empower/Chemstation, Unicorn, and SoftMax Pro)
• Ability to handle multiple tasks and adapt to changing priorities
• Strong organizational skills and attention to detail
• Strong verbal and written communication skills
• Ability to work in a collaborative environment
• Fun and driven atmosphere for rigorous scientific work