Scientist/Senior Scientist, Chemical Development

Nurix Therapeutics • The Woodlands, TX

281d

About The Position

Nurix is seeking a highly motivated and experienced Senior Scientist to join our Chemical Development team. The successful candidate will play a critical role in the development and optimization of chemical processes for the synthesis of novel therapeutic compounds. This position requires a deep understanding of organic chemistry, process development, and scale-up, as well as strong problem-solving skills and the ability to work collaboratively in a fast-paced environment.

Requirements

• Ph.D. in Organic Chemistry, Chemical Engineering, or a related field with 3+ years of relevant industry experience, or M.S. with 5+ years of experience
• Proven track record in chemical process development and scale-up
• Demonstrated experience with NDA supportive characterization studies (OVAT and/or DOE) and identification of critical process parameters (CPPs) for process validation
• Strong knowledge of modern synthetic organic chemistry techniques and methodologies
• Familiarity with analytical techniques such as HPLC, NMR, and mass spectrometry
• Experience with process optimization, including reaction kinetics, thermodynamics, and mechanistic studies
• Familiarity with regulatory requirements and guidelines for pharmaceutical development
• Excellent problem-solving skills and the ability to work independently and as part of a team
• Strong written and verbal communication skills
• Ability to manage multiple projects and prioritize tasks effectively

Nice To Haves

• Experience in the pharmaceutical industry, particularly in late stage process development
• Hands-on experience of scaling up processes in 5-20 L jacketed reaction vessels
• Experience in setting up and maintaining 1-20 L jacketed reaction vessels and auxiliary systems
• Experience in the use of Dynochem for process modeling
• Experience in the use of Design of Experiment software such as JMP and/or Design Expert

Responsibilities

• Characterize impurity profile of the manufacturing process and conduct impurity fate and purge experiments
• Design and conduct process characterization studies (OVAT and/or DOE) for the manufacturing process
• Mentor and provide guidance to junior scientists and research associates
• Design and develop robust and scalable chemical processes for the synthesis of small molecule therapeutics
• Optimize reaction conditions and improve process efficiencies to ensure high yield and purity
• Collaborate with cross-functional teams, including analytical chemistry, formulation, quality and regulatory to support drug development programs
• Troubleshoot and resolve complex synthetic and process-related challenges
• Author tech transfer documents and work with CROs/CDMOs to effectively and efficiently reproduce chemistry at various sites
• Prepare and review technical reports, protocols, and assist in the preparation of regulatory documentation, INDs, CTAs, NDAs and MAAs
• Present findings and updates to internal and external stakeholders
• Work up to 60% of the time in the laboratory

What This Job Offers

• Career Level: Senior
• Industry: Professional, Scientific, and Technical Services
• Education Level: Ph.D. or professional degree