Research Associate II, Drug Product Development

Scribe Therapeutics is seeking a Research Associate II with experience in formulation and downstream processing of lipid nanoparticles. The candidate will join the Process Sciences team to develop formulations for the company's CRISPR by Design™ platform. The ideal candidate should have a good understanding of lipid nanoparticle formulations and be able to collaborate effectively within various groups. This role requires a background in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences, or a related discipline, and experience with nanoparticles downstream processing and lipid nanoparticles formulation and characterization. Familiarity with CRISPR technologies and therapeutic approaches is preferred.

• Formulate and characterize lipid nanoparticle (LNPs) formulations both at small and large scales.
• Assist team to generate LNP formulations for in-house and R&D requirements.
• Perform data analysis using statistical software such as GraphPad PRISM, JMP, etc.
• Collaborate effectively within various groups and map out future needs and manage procurement of materials.
• Maintain detailed records of experimental protocols and data in electronic laboratory notebook.
• Perform additional duties and responsibilities as required based on the needs of the team.
• Have a good understanding of lipid nanoparticle formulations by various mixing and downstream processing techniques.
• Have experience with nanoparticles downstream processing, such as dialysis, Tangential Flow Filtration (TFF), centrifugal processing, and sterile filtration techniques.
• Have experience with drug delivery, bioconjugation, and surface modification chemistry.
• Have experience with lipid nanoparticles formulation and characterization.
• Possess excellent collaborative and communication skills and be a good team player.
• Have critical thinking skills and a mindset to deep dive into the LNP and gene editing field.
• Be familiar with CRISPR technologies and therapeutic approaches.
• Have knowledge of lipid chemistry, self-assembly characteristics, and their interaction with oligonucleotides.
• Have the ability to run me.

• BS with 2-4 years of experience, or MS with 1 year of experience in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences, or related discipline
• Experience in formulation and downstream processing of lipid nanoparticles
• Biophysical assessment of LNP systems
• Knowledge of lipid nanoparticle formulations by various mixing and downstream processing techniques
• Experience with nanoparticles downstream processing techniques such as dialysis, Tangential Flow Filtration (TFF), centrifugal processing, and sterile filtration
• Experience with drug delivery, bioconjugation, and surface modification chemistry (asset)
• Experience with lipid nanoparticles formulation and characterization
• Excellent collaborative and communication skills
• Critical thinking and mindset to deep dive into the LNP and gene editing field
• Familiarity with CRISPR technologies and therapeutic approaches (preferred)
• Knowledge of lipid chemistry, self-assembly characteristics, and their interaction with oligonucleotides (preferred)

• Salary commensurate with experience
• Intellectually stimulating and fast-paced environment
• Opportunity to work with CRISPR technologies and therapeutic approaches
• Opportunity to work with lipid chemistry and self-assembly characteristics
• Opportunity to work with nanoparticles downstream processing techniques
• Opportunity to work with drug delivery, bioconjugation, and surface modification chemistry
• Opportunity to develop formulations for CRISPR-based genetic medicine
• Collaborative and team-oriented work environment
• Opportunity for professional growth and development
• Comprehensive medical and other benefits included in the package