Principal Scientist, AAV and mRNA Engineering for CRISPR delivery

The job overview for this position is that Scribe Therapeutics is seeking a Principal Scientist to lead their efforts in engineering CRISPR enzyme delivery systems. The candidate will be responsible for optimizing key characteristics of CRISPR delivery systems, managing a team of scientists, and collaborating with internal and external stakeholders. They should have a PhD in a related discipline, at least 8 years of experience in molecular engineering, and expertise in AAV and mRNA delivery systems. This role offers opportunities for professional growth in a rapidly growing biotechnology start-up.

• Lead a research team to advance the CRISPR-by-design platform through optimizing CRISPR delivery systems
• Oversee the development and execution of pooled and arrayed screening for assessing critical characteristics of CRISPR delivery constructs
• Develop assays for characterizing CRISPR delivery constructs such as cell type specificity and expression
• Collaborate with pre-clinical therapeutic groups internally and externally to select optimized nucleic acid drug components
• Critically evaluate experiment data and communicate scientific findings through verbal presentations and written reports
• Develop and communicate research plans and timelines to senior leadership team and external collaborators
• Enable effective collaboration to ensure project execution within established timelines
• Oversee and manage a team of scientists and research associates
• Foster a driven, fast-paced, dynamic environment for rigorous science.

• PhD in Bioengineering, Biochemistry, Biophysics, Synthetic Biology, Genetics or related discipline
• At least 8 years of experience working in an academic or industry lab
• Proven track record of expertise in molecular engineering, designing reporter systems, screening in human cells, and readout by FACS and NGS
• Expertise in AAV optimization, production, and characterization and/or optimization of mRNA delivery systems
• Experience in managing and leading teams of scientists
• Expertise in molecular biology, RNA and protein analysis

• Salary commensurate with experience
• Intellectually stimulating and fast-paced environment
• Collegial work environment
• Equal opportunity employer
• Comprehensive medical and other benefits
• Additional incentives provided as part of the complete package
• Base pay wage range of $150,000-$190,000 per year
• Opportunity to engineer the future of therapeutics