About the position
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. The Oncology Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies, and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. The new Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.
Responsibilities
- Apply scientific, technical skills and functional knowledge to conduct in vivo pharmacology experiments and studies for T cell engager drug discovery programs.
- Characterize therapeutic candidates in vivo as part of the lead selection process, including tumor target antigen expression, T cell immunophenotyping, T cell dependent cytotoxicity and cytokine release assays building PK PD and efficacy relationship.
- Develop state of the art in vivo models, experimental protocols and relevant IO assays.
- Strengthen department's overall T-cell engager capabilities and expertise by employing innovative methods and technologies to test therapeutic hypotheses.
- Participate in implementation of program strategy, including xenograft models, PKPD and efficacy studies, and translational strategies to support regulatory filings.
- Execute experiments and deliver comprehensive high quality data sets to help decision making in a timely manner.
- Analyze results of complex experiments and present comprehensive technical or project reports at project team meetings.
- Mentor and train junior level research associates.
Requirements
- Bachelor's Degree with 7+ years of academic and/or industry experience, or
- Master's Degree with 5+ years of academic and/or industry experience, or
- Ph.D. or equivalent advanced degree in the Life Sciences with 2+ years of academic and/or industry experience.
Nice-to-haves
- Experience in in vivo pharmacology and expertise in preclinical development of T and/or NK cell engagers and immune-oncology.
- Experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models, IVIS imaging.
- Skilled and proficient at independently conducting xenograft mouse studies.
- Proficiency in cell culture, passaging and harvesting cells.
- Attention to detail with excellent organizational and record keeping skills.
- Extensive expertise with multi-parameter flow cytometry to investigate immune function of tumor infiltrating lymphocytes.
- Demonstrated expertise in utilizing relevant pharmacodynamic ex-vivo assays such as MSD ELISAs, qPCR, Luminex, western blotting.
- Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft Office for data analysis and figure generation.
- Excellent interpersonal and communication skills.
