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AbbVie - Worcester, MA

posted 2 months ago

Full-time - Senior
Worcester, MA
Chemical Manufacturing

About the position

The Senior Scientist I position in Protein Analytical Characterization at AbbVie involves contributing to the analytical and functional characterization of biologics and biopharmaceutical products. The role requires a strong background in protein analytical characterization, particularly mass spectrometry, to support various therapeutic areas and projects. The ideal candidate will engage in innovative problem-solving, collaborate with cross-functional teams, and mentor junior scientists, making a significant impact in a collaborative and innovative environment.

Responsibilities

  • Independently develop and execute mass spectrometry workflows for the characterization of biologics and biotherapeutics.
  • Resolve key project challenges by effectively utilizing available analytical tools, information, and technical expertise.
  • Develop, optimize and execute new analytical methods and techniques to characterize complex proteins/glycoproteins, antigens and novel protein-based therapeutics.
  • Exhibit scientific initiative and creativity in biologics characterization and screening beyond traditional mAbs to support BGM and TA projects, including multi-specifics, alternative non-Ig scaffolds, and fusion proteins.
  • Analyze, document, and report data concisely, formulate conclusions, and design follow-on experiments based on multidisciplinary data.
  • Provide direct mentorship and guidance to junior scientists and team members, fostering their scientific development and growth.
  • Provide project updates, analyses, and advice to cross-functional teams and senior management.
  • Present original work internally and at scientific conferences; may author or co-author scientific papers or patents.

Requirements

  • BS or MS or PhD in biology, chemistry, biochemistry or related field with typically 10+ (BS), 8+ (MS) or 0+ (PhD) years of experience.
  • Demonstrated theoretical and practical understanding of scientific discipline with the ability to learn and master innovative technologies.
  • In-depth experience with various mass spectrometry platforms (Orbitrap and Q-ToF), MS workflows for protein characterization, and MS software applications for analyzing both routine and complex data sets.
  • Robust analytical knowledge with demonstrated proficiency of various chromatographic and capillary electrophoresis techniques.
  • Experience in coding/programing and developing automated data solutions is a plus.
  • Working knowledge of biophysical and structural methods, such as DLS, DSF, HDX-MS, X-ray crystallography, etc., is a plus.
  • Direct experience with biologics, monoclonal antibodies and/or protein therapeutics is a plus.
  • Excellent organizational skills with the capacity to manage multiple projects and tasks simultaneously within timelines.
  • Goal-oriented team player with excellent verbal and written communication skills and a strong can-do attitude.

Nice-to-haves

  • Experience in coding/programing and developing automated data solutions.
  • Working knowledge of biophysical and structural methods, such as DLS, DSF, HDX-MS, X-ray crystallography, etc.
  • Direct experience with biologics, monoclonal antibodies and/or protein therapeutics.

Benefits

  • Paid time off (vacation, holidays, sick)
  • Medical/dental/vision insurance
  • 401(k)
  • Short-term incentive programs
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