About the position
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. The Oncology Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. The new Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.
Responsibilities
- Function as Pharmacology lead for multiple T cell engager drug discovery programs.
- Characterize therapeutic candidates in vivo as part of the lead selection process.
- Identify and develop state of the art in vivo models, experimental protocols and relevant IO assays.
- Participate in development and implementation of program strategy.
- Design, execute and deliver experiments comprehensive high quality data sets.
- Communicate program strategy and timelines to management.
- Manage a team of in vivo scientists providing guidance and mentoring.
- Lead initiatives related to development of new approaches / technologies within T-Cell engager strategy.
Requirements
- Bachelor's Degree with 10+ years of academic and/or industry experience, or
- Master's Degree with 8+ years of academic and/or industry experience, or
- Ph.D. or equivalent advanced degree in the Life Sciences with 6+ years of academic and/or industry experience.
- 2+ years of leadership experience.
Nice-to-haves
- PhD in immunology, cancer biology or relevant biological science with 6-8 years of relevant industry experience in in vivo pharmacology.
- Industry experience with a proven track record of independently driving in vivo strategy for immune cell engagers.
- Demonstrated ability to independently develop focused in vivo strategies.
- Demonstrated leadership in developing and deploying novel in vivo models.
- Experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models.
- Demonstrated expertise in utilizing relevant pharmacodynamic assays such as MSD ELISAs, immune profiling by flow cytometry, Luminex.
- Track record of building high functioning teams, managing and mentoring scientists.
- Excellent interpersonal and communication skills.
