Senior Director Health Economics and Outcomes Research (HEOR)

Vor Bio•Boston, MA

2d•$280,000 - $310,000•Onsite

About The Position

The Senior Director, HEOR leads the strategy and execution of health economics, real‑world evidence (RWE), and value demonstration activities to support global and US market access for the company’s lead asset(s). Operating in a resource‑lean, fast‑moving biotech, this leader builds the HEOR function from the ground up, partners cross‑functionally to shape clinical and evidence strategy, and ensures that payers, HTA bodies, clinicians, and patient communities understand the clinical, economic, and humanistic value of the therapy—especially critical in rare or high‑unmet‑need diseases. We are looking for a hands-on leader who can both set strategy and execute who is a patient-centric thinker. In this role you will need to anticipate payer needs and shape development accordingly. This role reports to the Chief Medical Affairs Officer and is a key contributor to launch readiness.

Requirements

Advanced degree (PhD, PharmD, MD, MPH, MS) in health economics, epidemiology, outcomes research, public health, or related field.
10+ years of HEOR/RWE experience in biotech/pharma, with at least 5 years in a leadership or strategic role.
Demonstrated success supporting pre‑launch and launch activities, ideally in rare disease or specialty therapeutics.
Deep expertise in economic modeling, RWE methodologies, PRO/COA development, and payer/HTA evidence requirements.
Proven ability to operate in lean, ambiguous, high‑growth environments.
Strong vendor management, scientific writing, and communication skills.
Experience in rare disease, autoimmune diseases or high‑cost specialty products.
Familiarity with US and ex‑US pricing and reimbursement landscapes.

Responsibilities

Develop and own the global and US HEOR strategy, aligned with clinical development, Medical Affairs, and Market Access priorities.
Build a fit‑for‑purpose HEOR roadmap including burden of illness, cost‑of‑illness, treatment patterns, PRO strategy, economic models, and RWE plans.
Serve as the internal expert on value, evidence, and payer expectations, advising senior leadership on implications for development and commercialization.
Design and oversee RWE studies, including natural history studies, chart reviews, registries, and external data collaborations.
Lead development and validation of patient‑reported outcomes (PROs) and other clinical outcome assessments (COAs) for regulatory and payer use.
Partner with Clinical Development to ensure trial designs incorporate endpoints relevant to payers, HTA bodies, and patient communities.
Manage vendors conducting HEOR and RWE studies; ensure scientific rigor, compliance, and timely delivery.
Lead development of global value dossiers (GVDs), AMCP dossiers, payer evidence decks, and HTA submissions.
Build and maintain cost‑effectiveness models, budget impact models, and scenario analyses to support pricing and reimbursement.
Provide HEOR insights to pricing strategy, including value‑based pricing rationale and competitive landscape assessments.
Support payer and HTA engagements with evidence, models, and scientific responses.
Partner closely with Medical Affairs on evidence generation, publications, and scientific exchange.
Collaborate with Market Access on payer strategy, pull‑through materials, and field training.
Work with Patient Advocacy to ensure patient‑centric evidence and outcomes are incorporated into HEOR plans.
Engage with Regulatory Affairs to align PRO/COA strategy with regulatory expectations.
Contribute to commercial launch planning, including value messaging and evidence‑based differentiation.
Represent the company with payers, HTA bodies, academic partners, KOLs, and RWE consortia.
Present HEOR and RWE findings at scientific congresses and in peer‑reviewed publications.
Build relationships with patient registries, data partners, and real‑world data providers.