Senior Analytical Scientist

Merck KGaA - Saint Louis, MO

Full-time - Mid Level

Saint Louis, MO

Chemical Manufacturing

About the position

Working in the Contract Testing, Development, and Manufacturing Organization (CTDMO) within the Life Sciences group of MilliporeSigma in St. Louis, MO, the Senior Analytical Scientist will serve as an individual contributor in the Process and Analytical Development organization. The role will involve working in a lab setting on analytical method development for external customers in the field of Antibody Drug Conjugates (ADC). In this role you will be involved with problem solving, working within project timelines, and contributing to documentation for method qualification and transfer into GMP manufacturing.

Responsibilities

• Serve as a subject matter expert in process and analytical development, perform troubleshooting / provide efficient and innovative solutions, and support transfer to GMP manufacturing
• Utilize customer-facing skills, document experimental results, communicate results to all stakeholders, author method development and qualification documents, contribute to information for customer proposals
• Serve as a project lead and ensure project deliverables are on quality and on time, develop multiple technical approach plans as needed to solve problems and mitigate risk, ensures process and methods are in place for efficient GMP start
• Lead project teams, influence exemplary work in other team members, lead process improvement initiatives, scout for new technologies / emerging trends, proactively consider the impact of quality, regulatory, manufacturing, and safety requirements when planning project activities

Requirements

• Bachelor's Degree in Chemistry, Biochemistry, Biomedical Engineering or other Scientific discipline with 6+ years of research experience
• Master's Degree in Chemistry, Biochemistry, Biomedical Engineering or other Scientific discipline with 2+ years of research experience
• PhD in Chemistry, Biochemistry, Biomedical Engineering or other Scientific discipline with 1+ years of research experience

Nice-to-haves

• Demonstrated skills in general and advanced laboratory techniques (theory and practice) to enable the development of novel approaches to solve complex process and analytical problems on fast-paced projects with changing priorities
• Current knowledge of small molecule or bio-therapeutics drug development process. Experience with antibody-drug conjugation
• Extensive hands-on experience and in-depth knowledge of the following bio/analytical technologies including: chromatography (HPLC/GC/IC/UPLC/SEC/HILIC/), protein characterization, protein functional assays and/or USP methodologies
• Robust expertise in biochemistry or organic chemistry
• Demonstrated success in contributing to the advancement of projects, project teams, and process improvements
• Excellent time management, attention to detail and strong communication skills (both written and verbal)
• Customer-facing experience
• Automation (medium to high-throughput) experience in an analytical setting and instrument maintenance / troubleshooting
• Working knowledge of Microsoft Word, Excel, and PowerPoint, as well as experience with advanced data acquisition and/or statistical software systems
• Ability to efficiently communicate concepts to both specialist and general audiences
• Ability to coordinate information exchange and manage data generated by contract testing labs
• Ability to comply with safety and company policies, practices and SSOPs

Benefits

• Diversity and inclusion initiatives
• Opportunities for professional development and growth