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Legend Biotech - Franklin Township, NJ

posted about 1 month ago

Full-time - Mid Level
Franklin Township, NJ
Professional, Scientific, and Technical Services

About the position

The Scientist II position at Legend Biotech is a critical role within the Technical Development team, responsible for establishing and optimizing analytical methods for cellular therapy products. The role emphasizes proficiency in flow cytometry method development, assay design, execution, and data analysis, ensuring high standards of quality and data integrity. The position requires maintaining accurate lab records and timely reporting of results, contributing to the advancement of immunotherapy treatments.

Responsibilities

  • Collaboratively drive projects to meet established timelines while maintaining the highest quality and data integrity standards.
  • Develop and optimize flow cytometry methods including multi-color phenotyping assays, intracellular staining, phosphorylation assays, and proliferation assays.
  • Establish and author SOPs/procedures for methods developed.
  • Maintain accurate and updated lab notebooks.
  • Maintain equipment and records for maintenance, calibration, and operation; contribute to maintenance of laboratory inventories.
  • Analyze data for trends and recommendations for scientific staff; present analyzed data within and across departmental meetings.
  • Participate in technology transfers of product-specific methods to QC, to external partners, and between sites; contribute to method qualification activities.
  • Provide analytical support for manufacturing and QC root cause investigations for OOS/OOE.
  • Author and/or review technical documents, protocols, and/or reports.
  • Procure and qualify required materials to perform experiments or testing.
  • May work directly with external vendors to resolve reagent or equipment issues.
  • Responsible for ensuring effective, accurate, and timely communication of project information.

Requirements

  • BS/MS degree in cell/molecular biology, immunology, or other related science; technical training/certification desirable.
  • BS degree: 3-5 years industry laboratory experience; MS degree: 1-3 years industry laboratory experience.
  • Experience in multi-color flow cytometry panel design and execution of multicolor panels.
  • Understanding of scientific principles for analytical methods in support of process and product characterization such as flow cytometry, cytokine measurements, cell proliferation measurements, apoptosis measurements, etc.
  • Expertise with aseptic technique and mammalian cell culture; primary T cell culture experience desired.
  • Ability to communicate clearly with a variety of cross-functional teams.
  • Detail-oriented with expertise in problem solving and solid decision-making abilities.
  • Experience writing laboratory SOPs and technical instructions is preferred.
  • Demonstrated ability to work independently and in a team environment.

Nice-to-haves

  • Experience writing laboratory SOPs and technical instructions is preferred.
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