Prime Medicine - Cambridge, MA
posted 1 day ago
About the position
Prime Medicine is currently seeking a talented and motivated Scientist I or II with expertise in HPLC and mass spectrometry to join the analytical development team in Prime's Technical Development and Operations group. The candidate will play a key role in the application and development of a variety of HPLC, mass spectrometry (MS) and biophysical assays for the characterization of Prime editing components, drug substances and drug products across Prime's portfolio, including long oligonucleotides (guide RNAs), conjugates, lipid nanoparticles (LNP), proteins, etc. This is a hands-on role that provides an exciting opportunity to gain direct experience with all aspects of analytical development. The ideal candidate will excel as a member of a cross-functional team that works closely with the process development, formulation, chemistry, manufacturing, pharmacology, biology, and quality teams to advance the Prime Editing therapeutic product pipeline. The ideal candidate is an energetic learner, highly dependable, detail-oriented, multitasking bench scientist with demonstrated abilities for generating high-quality data in a multidisciplinary team setting.
Responsibilities
- Assist with all aspects of analytical development, including new assay development, qualification and validation, and supporting routine sample analysis and stability testing.
- Contribute to new analytical method development to augment Prime's analytical capabilities, including release, characterization, stability, and activity/potency assays.
- Conduct sample analysis for the characterization and release testing of Prime editing components, following experimental design, protocols, and standard operating procedures (SOP).
- Contribute to analytical sections in support of regulatory submissions.
- Assist in method transfer to CTLs (contract testing labs) and CDMOs (contract development and manufacturing organizations).
- Maintain electronic lab notebook following data integrity principles and practices.
- Effectively communicate results to multi-disciplinary teams in oral and written formats.
- Willingness to learn new skills and processes.
Requirements
- BS/MS/PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline.
- At least 5 years experience in the biotechnology or pharmaceutical industry for BS candidates, 3-6 years for MS and 0-3 years for PhD candidates.
- Experience with HPLC and/or LC-MS based analytical method development, qualification and/or validation.
- Experience with macromolecule analysis (proteins, antibodies, oligonucleotides, mRNA, etc.) is a plus.
- Capable of continuous improvement, learning new things, open-minded, curious, highly organized and detail-oriented.
- Strong collaborator with cross-functional teams.
- Ability to adapt quickly in a fast-paced environment with changing priorities.
- Highly self-motivated, driven, can-do, make it happen attitude.
