Scientist I, Early Discovery, CAR T Cell Therapy

$110,200 - $135,000/Yr

Arsenal Biosciences - South San Francisco, CA

Full-time - Entry Level

South San Francisco, CA

About the position

Arsenal Biosciences is seeking a Scientist I for Early Discovery in CAR T Cell Therapy, based in South San Francisco. This role focuses on developing innovative methods to enhance CAR T-cell therapies for solid tumors, contributing to the company's mission to defeat cancer. The ideal candidate will collaborate with a diverse team of experts, driving scientific and technical innovation in synthetic immunology and cell therapy.

Responsibilities

• Develop novel methods to investigate and understand the biochemical and functional properties of specific receptor designs.
• Lead high-throughput screening of synthetic receptors for a portfolio of cell therapy applications.
• Work closely with Molecular Biology experts to create DNA constructs and libraries that encode immune receptor domains.
• Stay up-to-date with current research related to multiplexing readouts, synthetic immunology, and cell therapy.
• Collaborate with the ArsenalBio team to advance scientific and technical innovation in these areas.
• Summarize and synthesize data across experiments and present findings to all levels of the organization.
• Offer scientific leadership and mentorship to research associates while effectively organizing and prioritizing tasks across multiple projects.
• Work collaboratively and proactively with colleagues in automation, computational biology, NGS and discovery in a matrixed team structure.

Requirements

• PhD in immunology, molecular or cellular biology or a related field with 0-2 years of relevant experience, Masters with 5+ years experience, or Bachelors with 7+ years experience.
• In-depth knowledge of CAR-T, SynNotch, and the synthetic receptor field.
• Experience with primary cell culture and functional screening of human immune cells.
• Experience in flow cytometry including developing flow cytometry panels.
• Ability to develop methods compatible with high throughput screening and collaborate with automation engineers.
• Familiarity with R or similar environments for pipelining of routine data analysis.
• Familiarity with cloning methods and working knowledge of NGS technologies and workflows is a plus.
• Outstanding written and oral communication skills and the ability to organize and communicate complex data sets clearly and concisely.

Nice-to-haves

• Industry experience is preferred but not required.
• Ability to multi-task and work in collaboration with peers within a fast-paced team environment.
• Demonstrated entrepreneurial behaviors such as agility, accountability, transparency, and resourcefulness.

Benefits

• Health savings account
• Health insurance
• Dental insurance
• Parental leave
• Vision insurance
• Flexible schedule