University Of Michigan (The Regents @ Ann Arbor) - Ann Arbor, MI

posted about 1 month ago

- Entry Level
Hybrid - Ann Arbor, MI
10,001+ employees
Educational Services

About the position

Our lab is interested in understanding the mechanisms by which the lung epithelium responds to injury. We study mechanisms of injury/inflammation and regeneration after injury. Epithelial injury and a failure of epithelial regeneration is thought to drive the development of lung diseases such as ARDS (including COVID-19), fibrosis, and emphysema. Specifically, we are exploring the mechanisms underlying proliferation and differentiation of alveolar epithelial progenitor or stem cells. We have identified ?-catenin, HIF, and TGF? signaling as important drivers. We also study the epithelial inflammatory and host defense responses to bacterial and viral infection, specifically epithelial-immune cell crosstalk. We use mouse and cell culture models to study mechanisms. The mouse work involves lineage tracing and inducible cell-specific gene deficient mice, and primary epithelial cell culture/organoid work allows us to further dissect mechanism. We use confocal imaging, immunostaining, fluorescence in situ hybridization (FISH), single cell RNA sequencing, proteomics, and flow assisted cytometry sorting (FACS). We aim to address important questions and make novel discoveries that significantly enhance our understanding of lung biology and disease. We hope that our discoveries may ultimately lead to the development of therapies for infectious, inflammatory, and fibrotic lung diseases.

Responsibilities

  • Take a leading role and work closely with the PI in the development and implementation of the research program.
  • Conduct research on mechanisms of injury/inflammation and regeneration after injury.
  • Explore mechanisms underlying proliferation and differentiation of alveolar epithelial progenitor or stem cells.
  • Study epithelial inflammatory and host defense responses to bacterial and viral infection.
  • Utilize mouse and cell culture models for research.
  • Perform lineage tracing and work with inducible cell-specific gene deficient mice.
  • Conduct primary epithelial cell culture/organoid work.
  • Use confocal imaging, immunostaining, FISH, single cell RNA sequencing, proteomics, and FACS.

Requirements

  • PhD (completed or near completion) or MS or BS with significant experience in cell biology, developmental biology, immunology, physiology, or related field.
  • Outstanding organizational skills and attention to detail.
  • Ability to work hard and be flexible in a fast-paced environment.
  • Ability to get along with other lab members.
  • Prior experience with rodents, cell culture, microscopy, RNA/qPCR, western blotting, computational biology, and/or flow cytometry is helpful.
  • At least one first authored manuscript in a peer-reviewed journal is required for candidates with a PhD.

Nice-to-haves

  • Interest in studying stem cells and tissue regeneration.
  • Interest in immune-epithelial crosstalk.
  • Experience with organoid culture and scRNAseq.

Benefits

  • Excellent medical, dental and vision coverage effective on your very first day
  • 2:1 Match on retirement savings
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