Research Fellow-Translational Neuroproteomics-Rossoll lab
About The Position
The Translational Neuroproteomics Laboratory (Rossoll Lab) is seeking a highly motivated Postdoctoral Research Fellow to join our Foundation-funded project. The project aims to define the proteomic composition and molecular environment of pathological phospho-TDP-43 (pTDP-43) aggregates in human brain tissue and determine how these associated proteins contribute to neurodegeneration in sporadic frontotemporal lobar degeneration (FTLD-TDP). The work integrates microscope-guided photolabeling/proximity proteomics in FFPE human brain tissue, affinity purification, data-independent acquisition LC-MS/MS, multiplexed spatial biology, proteomics data analysis, and functional validation in cellular and organotypic brain-slice culture models of TDP-43 proteinopathy. This position offers an opportunity to work in a highly interactive neuroscience community at Mayo Clinic Florida, with access to world-class facilities, including the Multiomics Mass Spectrometry (MMS) core, and the Mayo Clinic brain bank.
Requirements
- PhD or equivalent degree.
- Demonstrated potential for research as evidenced by training and peer-reviewed publications.
- Ability to become competitive for national research grants.
- Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.
Nice To Haves
- Experience with microscope-guided photolabeling/proximity proteomics in FFPE human brain tissue.
- Experience with affinity purification.
- Experience with data-independent acquisition LC-MS/MS.
- Experience with multiplexed spatial biology.
- Experience with proteomics data analysis.
- Experience with functional validation in cellular and organotypic brain-slice culture models.
Responsibilities
- Define the proteomic composition and molecular environment of pathological phospho-TDP-43 (pTDP-43) aggregates in human brain tissue.
- Determine how associated proteins contribute to neurodegeneration in sporadic frontotemporal lobar degeneration (FTLD-TDP).
- Integrate microscope-guided photolabeling/proximity proteomics in FFPE human brain tissue.
- Perform affinity purification.
- Conduct data-independent acquisition LC-MS/MS.
- Utilize multiplexed spatial biology techniques.
- Analyze proteomics data.
- Perform functional validation in cellular and organotypic brain-slice culture models of TDP-43 proteinopathy.
Benefits
- Medical: Multiple plan options.
- Dental: Delta Dental or reimbursement account for flexible coverage.
- Vision: Affordable plan with national network.
- Pre-Tax Savings: HSA and FSAs for eligible expenses.
- Retirement: Competitive retirement package to secure your future.
- Continuing education and advancement opportunities.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
