Principal Scientist - Cell Therapy Translational Research

Bristol Myers Squibb • Seattle, WA

17h • Onsite

About The Position

The candidate will join the Cellular Therapy Translational Research group in Seattle, WA and will support cell therapy development programs in autoimmune and inflammatory diseases. The successful candidate will be an experienced, self-motivated, and resourceful researcher responsible for driving and implementing translational development strategies and clinical biomarker plans for BMS cellular therapy clinical studies. The individual will work with contract research organizations, and internal and external collaborators, to design, execute, and interpret translationally focused experiments and analyses. Activities include biomarker identification, generation and analysis of data that support pharmacodynamic evaluation and mechanism of action in the clinical trial setting to inform development of cell therapy products, as well as contribute to relevant global regulatory submission activities to advance cellular therapeutics.

Requirements

• Bachelor’s Degree 8+ years of academic and / or industry experience Or Master’s Degree 6+ years of academic and / or industry experience Or Ph.D. or equivalent advanced degree in the Life Sciences 4+ years of academic and / or industry experience
• Expertise in immunology or cellular biology is required
• Excellent communication and interpersonal skills, evidenced by strong ability to interact with and influence research scientists, project teams, outside collaborators and commercial vendors
• Detail-oriented with the ability to identify and implement creative solutions
• Ability to prioritize and manage time efficiently

Nice To Haves

• M.S. or Ph.D. in immunology, molecular and cellular biology, or relevant discipline
• M.S. with 10+ years or Ph.D with 5+ years of experience, preferably in the biotechnology or pharmaceutical industry setting, or demonstrated deep experience in immunology or cell therapy academic research
• knowledge of fundamentals of autoimmune and inflammatory diseases is desirable
• Familiarity with and experience in the drug development process from IND filing to market authorization in an industry setting is desirable
• Expertise in developing and analyzing biomarkers for clinical trials
• Experience analyzing high content (eg, transcriptomic, proteomic) datasets

Responsibilities

• Develop and implement end-to-end translational research strategies for cell therapy clinical trials
• Partner with biostatisticians and computational biologists to provide timely analysis and communication of data and present its context and impact
• Develop concepts and mechanism of action hypotheses identifying distinguishing characteristics of BMS cell therapy products alone or in combination with other therapies
• Maintain a deep understanding of biomarker assays including flow cytometry, transcriptomics, proteomics and the application and use of these technologies in the clinical trial setting
• Independently manage internal projects in cell therapy drug development
• Serve on internal cross functional project teams and committees as scientific functional lead
• Oversight and management of CROs and academic collaborators
• Communicate regularly and prepare and make presentations within the department, externally, and to internal governance committees as required.
• Contribute to the writing of investigator brochures, IND applications, clinical protocols, regulatory annual reports, and other regulatory documents when appropriate
• Support regulatory submissions and interactions, write/review translational sections for global regulatory response and queries

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
• All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree