AbbVie - North Chicago, IL

posted 2 months ago

Full-time - Principal
North Chicago, IL
10,001+ employees
Chemical Manufacturing

About the position

The Principal Research Scientist I at AbbVie plays a crucial role in supporting the development of novel small molecules across various therapeutic areas. This position involves close collaboration with multidisciplinary project teams to develop and execute Quantitative, Translational and ADME Sciences (QTAS) and pharmacokinetics/pharmacodynamics (PK/PD) strategies, ensuring the advancement of AbbVie's pipeline of innovative therapies. The role requires a deep understanding of ADME sciences and the ability to communicate effectively with stakeholders to influence project decisions.

Responsibilities

  • Serve as a QTAS representative on multidisciplinary project teams supporting the development of novel small molecules.
  • Collaborate with project team members (e.g., discovery, toxicology, clinical pharmacology) to generate relevant data guiding target validation, biomarker selection, and candidate selection.
  • Develop and drive the QTAS and PK/PD strategy for small molecule discovery, preclinical, and clinical development of projects.
  • Effectively communicate QTAS and PK/PD strategy and knowledge to project teams, functional leaders, and other key stakeholders.
  • Demonstrate thorough understanding of ADME sciences and PK/PD aspects necessary to optimize drug candidates.
  • Coordinate and request ADME, PK and PK/PD studies in a timely manner and communicate protocols, timelines, needs and results back to team.
  • Integrate ADME, PK, PK/PD data with discovery biology data and provide thought leadership to project teams as a functional representative.
  • Prepare QTAS sections of regulatory submission documents (IND, IB, NDA); provide responses to regulatory questions and ensure generation of appropriate reports.
  • Mentor junior project representatives.

Requirements

  • PhD in Biochemistry, Drug Metabolism, Pharmacokinetics, Pharmaceutical Sciences, or related area with 6+ years of experience in the pharmaceutical or biotechnology industry, or MS with 12+ years, or BS with 14+ years of industry experience.
  • Experience independently representing QTAS on small molecule project teams is required.
  • Expertise in PK analysis and relevant data analysis software such as Phoenix/WinNonlin is required.
  • Strong understanding of Drug Metabolism, PK, PK/PD modeling, human PK and DDI prediction strategies.
  • Demonstrated scientific leadership including generating original scientific investigative strategies and guiding those efforts to an effective and productive outcome.
  • Recognized expert in his/her discipline with a demonstrated publication or patent record; lead/senior author contributions a plus.
  • Ability to influence, negotiate and communicate effectively with both internal and external stakeholders.
  • Highly motivated, self-driven and results-oriented with excellent communication and presentation skills.

Nice-to-haves

  • Expertise with novel modalities is preferred.
  • Ability to quickly adapt in-house visualization tools for data interpretation and presentation.
  • High degree of flexibility in adapting to different projects and people; excellent networking and relationship-building skills.

Benefits

  • Paid time off (vacation, holidays, sick)
  • Medical/dental/vision insurance
  • 401(k)
  • Short-term incentive programs
  • Long-term incentive programs
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