Assistant Principal Scientist, Protein Drug Product Development

$127,000 - $178,533/Yr

Insmed Incorporated - Bridgewater Township, NJ

Full-time - Senior

Bridgewater Township, NJ

Professional, Scientific, and Technical Services

About the position

The Assistant Principal Scientist in Protein Drug Product Development at Insmed will lead the formulation and process development of biotherapeutic candidates. This role involves utilizing advanced biophysical techniques for drug product discovery, ensuring the stability and efficacy of protein therapeutics, and facilitating tech transfer activities. The position requires strong collaboration with internal and external partners to drive projects forward, along with the ability to communicate findings effectively through reports and presentations.

Responsibilities

• Lead biotherapeutic drug product discovery/engineering activities across different therapeutic areas.
• Utilize protein biochemistry/biophysical techniques to inform on optimization of formulation and process to support development candidate nomination.
• Evaluate, select, and apply standard engineering procedures to process design and lead tech transfer activities.
• Present findings in internal and external meetings; author technical reports and publications.
• Communicate with internal and external partners to progress projects.

Requirements

• PhD in Biochemistry, Molecular Biology, Biotechnology, Enzymology, Chemical Engineering, Bioengineering, or a related field with 6+ years or MS with 10+ years of relevant hands-on experience.
• Solid understanding of molecular biology, cell biology, and protein biochemistry.
• Experience developing formulations and processes to stabilize protein therapeutics.
• Protein production experience using prokaryotic and eukaryotic host systems.
• Experience using automated chromatography workstations (e.g., AKTA FPLCs) and employing multi-dimensional purification strategies.
• Experience using analytical techniques to characterize proteins including light scattering (e.g., DLS, SEC-MALS), mass photometry, circular dichroism, and thermal stability (e.g., DSC, DSF).
• Experience investigating biotherapeutic half-life extension is a plus.
• Target affinity characterization experience (e.g., ITC, SPR, BLI) is a plus.
• Experience with crystallization techniques (e.g., co-crystallization, seeding, soaking, etc.) and interpreting crystallographic data is a plus.
• Familiarity with chemistry and protein computational techniques is a plus.
• A record of scientific publication employing the skills listed above.
• Experience leading functions and teams is a plus.
• Familiarity with experiment documentation using electronic lab notebook.
• Strong written and oral communication skills are required.
• Detail-oriented, highly organized, and able to multi-task with multiple projects.

Nice-to-haves

• Experience investigating biotherapeutic half-life extension.
• Target affinity characterization experience (e.g., ITC, SPR, BLI).
• Experience with crystallization techniques and interpreting crystallographic data.
• Familiarity with chemistry and protein computational techniques.

Benefits

• Flexible approach to where and how we work, regionally based
• Competitive compensation package including bonus
• Stock options and RSU awards
• Employee Stock Purchase Plan (ESPP)
• Flexible Vacation Policy
• Generous paid holiday schedule and winter break
• 401(k) plan with company match
• Medical, dental, and vision plans
• Company-provided Life and Accidental Death & Dismemberment (AD&D) insurance
• Company-provided short and long-term disability benefits
• Unique offerings of pet, legal, and supplemental life insurance
• Flexible spending accounts for medical and dependent care
• Accident and Hospital Indemnity insurance
• Employee Assistance Program (EAP)
• Mental Health on-line digital resource
• Well-being reimbursement
• Paid leave benefits for new parents
• Paid time off to volunteer
• On-site, no-cost fitness center at our U.S. headquarters